Detailed information of TA system TA226153

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1289738..1290336
• Replicon: chromosome
• Accession: NZ_CP087791
• Organism: Moraxella bovis strain SAM57964

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP090_RS06640
• Protein ID: WP_078275306.1
• Coordinates: 1289738..1290016 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LP090_RS06645
• Protein ID: WP_276001721.1
• Coordinates: 1290046..1290336 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP090_RS06625 (LP090_06570)	1284752..1285111	-	360	WP_115368637.1	hypothetical protein	-
LP090_RS06630 (LP090_06575)	1285108..1289043	-	3936	WP_264678348.1	phage tail protein	-
LP090_RS06635 (LP090_06580)	1289068..1289652	-	585	WP_264676215.1	tail assembly protein	-
LP090_RS06640 (LP090_06585)	1289738..1290016	+	279	WP_078275306.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP090_RS06645 (LP090_06590)	1290046..1290336	+	291	WP_276001721.1	HigA family addiction module antitoxin	Antitoxin
LP090_RS06650 (LP090_06595)	1290308..1291084	-	777	WP_078275308.1	C40 family peptidase	-
LP090_RS06655 (LP090_06600)	1291152..1291340	-	189	WP_078275309.1	hypothetical protein	-
LP090_RS06660 (LP090_06605)	1291337..1291879	-	543	WP_078275310.1	antA/AntB antirepressor family protein	-
LP090_RS06665 (LP090_06610)	1292052..1292282	+	231	WP_078275311.1	Arc family DNA-binding protein	-
LP090_RS06670 (LP090_06615)	1292324..1293007	-	684	WP_078275312.1	phage minor tail protein L	-
LP090_RS06675 (LP090_06620)	1293004..1293393	-	390	WP_078275313.1	hypothetical protein	-
LP090_RS06680 (LP090_06625)	1293429..1293761	-	333	WP_078275314.1	phage tail protein	-
LP090_RS06685 (LP090_06630)	1293758..1293919	-	162	WP_158079719.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1265183..1339828	74645

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-90)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10491.92 Da
• Isoelectric Point: 5.0474

>T226153 WP_078275306.1 NZ_CP087791:1289738-1290016 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Nucleotide

• Length: 279 bp

>T226153 NZ_CP122316:c1372014-1371838 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10596.11 Da
• Isoelectric Point: 6.7228

>AT226153 WP_276001721.1 NZ_CP087791:1290046-1290336 [Moraxella bovis]
MRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELRLAETT
LGDSLDFISPHEVAHA

Nucleotide

• Length: 291 bp

>AT226153 NZ_CP122316:c1371792-1371376 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA