Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1817395..1817993 Replicon chromosome
Accession NZ_CP087784
Organism Moraxella bovis strain SAM57973

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP100_RS09090 Protein ID WP_078275306.1
Coordinates 1817395..1817673 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LP100_RS09095 Protein ID WP_078275307.1
Coordinates 1817688..1817993 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP100_RS09085 (LP100_08995) 1816725..1817309 - 585 WP_264676215.1 tail assembly protein -
LP100_RS09090 (LP100_09000) 1817395..1817673 + 279 WP_078275306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP100_RS09095 (LP100_09005) 1817688..1817993 + 306 WP_078275307.1 HigA family addiction module antitoxin Antitoxin
LP100_RS09100 (LP100_09010) 1817965..1818741 - 777 WP_078275308.1 C40 family peptidase -
LP100_RS09105 (LP100_09015) 1818809..1818997 - 189 WP_078275309.1 hypothetical protein -
LP100_RS09110 (LP100_09020) 1818994..1819590 - 597 WP_264676214.1 antA/AntB antirepressor family protein -
LP100_RS09115 (LP100_09025) 1819763..1819993 + 231 WP_078275311.1 Arc family DNA-binding protein -
LP100_RS09120 (LP100_09030) 1820035..1820718 - 684 WP_264676213.1 phage minor tail protein L -
LP100_RS09125 (LP100_09035) 1820715..1821104 - 390 WP_078275313.1 hypothetical protein -
LP100_RS09130 (LP100_09040) 1821140..1821472 - 333 WP_078275314.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1808359..1842133 33774


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226145 WP_078275306.1 NZ_CP087784:1817395-1817673 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226145 NZ_CP122316:c104745-104416 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11173.81 Da        Isoelectric Point: 7.3174

>AT226145 WP_078275307.1 NZ_CP087784:1817688-1817993 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Download         Length: 306 bp

>AT226145 NZ_CP122316:c105083-104766 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References