Detailed information of TA system TA226138

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 100036..100642
• Replicon: chromosome
• Accession: NZ_CP087784
• Organism: Moraxella bovis strain SAM57973

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP100_RS00490
• Protein ID: WP_228157738.1
• Coordinates: 100307..100642 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LP100_RS00485
• Protein ID: WP_078274722.1
• Coordinates: 100036..100317 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP100_RS00460 (LP100_00465)	95734..96492	+	759	WP_078274726.1	YciK family oxidoreductase	-
LP100_RS00465 (LP100_00470)	96602..97927	+	1326	WP_112741690.1	hemolysin family protein	-
LP100_RS00470 (LP100_00475)	98072..98794	+	723	WP_029103568.1	nitroreductase family protein	-
LP100_RS00475 (LP100_00480)	98834..99046	-	213	WP_078274724.1	hypothetical protein	-
LP100_RS00480 (LP100_00485)	99162..99986	-	825	WP_078274723.1	site-specific integrase	-
LP100_RS00485 (LP100_00490)	100036..100317	-	282	WP_078274722.1	NadS family protein	Antitoxin
LP100_RS00490 (LP100_00495)	100307..100642	-	336	WP_228157738.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP100_RS00495 (LP100_00500)	100706..101866	-	1161	WP_078274721.1	zonular occludens toxin domain-containing protein	-
LP100_RS00500 (LP100_00505)	101952..102245	-	294	WP_078274720.1	DUF2523 family protein	-
LP100_RS00505 (LP100_00510)	102242..103117	-	876	WP_162860331.1	virulence factor TspB C-terminal domain-related protein	-
LP100_RS00510 (LP100_00515)	103610..103867	-	258	WP_112741693.1	hypothetical protein	-
LP100_RS00515 (LP100_00520)	103986..104315	+	330	WP_264676042.1	hypothetical protein	-
LP100_RS00520 (LP100_00525)	104438..104683	+	246	WP_078274709.1	hypothetical protein	-
LP100_RS00525 (LP100_00530)	104970..105245	+	276	WP_078274708.1	hypothetical protein	-
LP100_RS00530 (LP100_00535)	105240..105395	-	156	WP_158079680.1	hypothetical protein	-
LP100_RS00535	105447..105581	-	135	WP_264676041.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-84)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12636.69 Da
• Isoelectric Point: 10.0972

>T226138 WP_228157738.1 NZ_CP087784:c100642-100307 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Nucleotide

• Length: 336 bp

>T226138 NZ_CP122315:c3500140-3499886 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10425.98 Da
• Isoelectric Point: 10.0023

>AT226138 WP_078274722.1 NZ_CP087784:c100317-100036 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Nucleotide

• Length: 282 bp

>AT226138 NZ_CP122315:c3500388-3500137 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA