Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 100036..100642 Replicon chromosome
Accession NZ_CP087784
Organism Moraxella bovis strain SAM57973

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP100_RS00490 Protein ID WP_228157738.1
Coordinates 100307..100642 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LP100_RS00485 Protein ID WP_078274722.1
Coordinates 100036..100317 (-) Length 94 a.a.

Genomic Context

LP100_RS00460LP100_RS00465LP100_RS00470LP100_RS00515LP100_RS00520LP100_RS00525LP100_RS00475LP100_RS00480LP100_RS00485LP100_RS00490LP100_RS00495LP100_RS00500LP100_RS00505LP100_RS00510LP100_RS00530LP100_RS00535
Location: 95734..96492 (759 bp)
Type: Others
Protein ID: WP_078274726.1
Location: 96602..97927 (1326 bp)
Type: Others
Protein ID: WP_112741690.1
Location: 98072..98794 (723 bp)
Type: Others
Protein ID: WP_029103568.1
Location: 103986..104315 (330 bp)
Type: Others
Protein ID: WP_264676042.1
Location: 104438..104683 (246 bp)
Type: Others
Protein ID: WP_078274709.1
Location: 104970..105245 (276 bp)
Type: Others
Protein ID: WP_078274708.1
Location: 98834..99046 (213 bp)
Type: Others
Protein ID: WP_078274724.1
Location: 99162..99986 (825 bp)
Type: Others
Protein ID: WP_078274723.1
Location: 100036..100317 (282 bp)
Type: Antitoxin
Protein ID: WP_078274722.1
Location: 100307..100642 (336 bp)
Type: Toxin
Protein ID: WP_228157738.1
Location: 100706..101866 (1161 bp)
Type: Others
Protein ID: WP_078274721.1
Location: 101952..102245 (294 bp)
Type: Others
Protein ID: WP_078274720.1
Location: 102242..103117 (876 bp)
Type: Others
Protein ID: WP_162860331.1
Location: 103610..103867 (258 bp)
Type: Others
Protein ID: WP_112741693.1
Location: 105240..105395 (156 bp)
Type: Others
Protein ID: WP_158079680.1
Location: 105447..105581 (135 bp)
Type: Others
Protein ID: WP_264676041.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LP100_RS00460 (LP100_00465)95734..96492+759WP_078274726.1YciK family oxidoreductase-
LP100_RS00465 (LP100_00470)96602..97927+1326WP_112741690.1hemolysin family protein-
LP100_RS00470 (LP100_00475)98072..98794+723WP_029103568.1nitroreductase family protein-
LP100_RS00475 (LP100_00480)98834..99046-213WP_078274724.1hypothetical protein-
LP100_RS00480 (LP100_00485)99162..99986-825WP_078274723.1site-specific integrase-
LP100_RS00485 (LP100_00490)100036..100317-282WP_078274722.1NadS family proteinAntitoxin
LP100_RS00490 (LP100_00495)100307..100642-336WP_228157738.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LP100_RS00495 (LP100_00500)100706..101866-1161WP_078274721.1zonular occludens toxin domain-containing protein-
LP100_RS00500 (LP100_00505)101952..102245-294WP_078274720.1DUF2523 family protein-
LP100_RS00505 (LP100_00510)102242..103117-876WP_162860331.1virulence factor TspB C-terminal domain-related protein-
LP100_RS00510 (LP100_00515)103610..103867-258WP_112741693.1hypothetical protein-
LP100_RS00515 (LP100_00520)103986..104315+330WP_264676042.1hypothetical protein-
LP100_RS00520 (LP100_00525)104438..104683+246WP_078274709.1hypothetical protein-
LP100_RS00525 (LP100_00530)104970..105245+276WP_078274708.1hypothetical protein-
LP100_RS00530 (LP100_00535)105240..105395-156WP_158079680.1hypothetical protein-
LP100_RS00535105447..105581-135WP_264676041.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-84)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12636.69 Da        Isoelectric Point: 10.0972

>T226138 WP_228157738.1 NZ_CP087784:c100642-100307 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Download         Length: 336 bp

>T226138 NZ_CP122315:c3500140-3499886 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10425.98 Da        Isoelectric Point: 10.0023

>AT226138 WP_078274722.1 NZ_CP087784:c100317-100036 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Download         Length: 282 bp

>AT226138 NZ_CP122315:c3500388-3500137 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References