Detailed information of TA system TA226117

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 99606..100212
• Replicon: chromosome
• Accession: NZ_CP087771
• Organism: Moraxella bovis strain SAM109244

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP127_RS00490
• Protein ID: WP_228157738.1
• Coordinates: 99877..100212 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LP127_RS00485
• Protein ID: WP_078274722.1
• Coordinates: 99606..99887 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP127_RS00460 (LP127_00465)	95304..96062	+	759	WP_078274726.1	YciK family oxidoreductase	-
LP127_RS00465 (LP127_00470)	96172..97497	+	1326	WP_112741690.1	hemolysin family protein	-
LP127_RS00470 (LP127_00475)	97642..98364	+	723	WP_029103568.1	nitroreductase family protein	-
LP127_RS00475 (LP127_00480)	98404..98616	-	213	WP_078274724.1	hypothetical protein	-
LP127_RS00480 (LP127_00485)	98732..99556	-	825	WP_078274723.1	site-specific integrase	-
LP127_RS00485 (LP127_00490)	99606..99887	-	282	WP_078274722.1	NadS family protein	Antitoxin
LP127_RS00490 (LP127_00495)	99877..100212	-	336	WP_228157738.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP127_RS00495 (LP127_00500)	100276..101436	-	1161	WP_078274721.1	zonular occludens toxin domain-containing protein	-
LP127_RS00500 (LP127_00505)	101522..101815	-	294	WP_078274720.1	DUF2523 family protein	-
LP127_RS00505 (LP127_00510)	101812..102687	-	876	WP_162860331.1	virulence factor TspB C-terminal domain-related protein	-
LP127_RS00510 (LP127_00515)	103180..103437	-	258	WP_112741693.1	hypothetical protein	-
LP127_RS00515 (LP127_00520)	103556..103885	+	330	WP_264676042.1	hypothetical protein	-
LP127_RS00520 (LP127_00525)	104008..104253	+	246	WP_078274709.1	hypothetical protein	-
LP127_RS00525 (LP127_00530)	104540..104815	+	276	WP_078274708.1	hypothetical protein	-
LP127_RS00530 (LP127_00535)	104810..104965	-	156	WP_158079680.1	hypothetical protein	-
LP127_RS00535	105017..105151	-	135	WP_264676041.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-84)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12636.69 Da
• Isoelectric Point: 10.0972

>T226117 WP_228157738.1 NZ_CP087771:c100212-99877 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Nucleotide

• Length: 336 bp

>T226117 NZ_CP122302:25126-25431 [Salmonella enterica]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10425.98 Da
• Isoelectric Point: 10.0023

>AT226117 WP_078274722.1 NZ_CP087771:c99887-99606 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Nucleotide

• Length: 282 bp

>AT226117 NZ_CP122302:24906-25124 [Salmonella enterica]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA