Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 99606..100212 Replicon chromosome
Accession NZ_CP087771
Organism Moraxella bovis strain SAM109244

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP127_RS00490 Protein ID WP_228157738.1
Coordinates 99877..100212 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LP127_RS00485 Protein ID WP_078274722.1
Coordinates 99606..99887 (-) Length 94 a.a.

Genomic Context

LP127_RS00460LP127_RS00465LP127_RS00470LP127_RS00515LP127_RS00520LP127_RS00525LP127_RS00475LP127_RS00480LP127_RS00485LP127_RS00490LP127_RS00495LP127_RS00500LP127_RS00505LP127_RS00510LP127_RS00530LP127_RS00535
Location: 95304..96062 (759 bp)
Type: Others
Protein ID: WP_078274726.1
Location: 96172..97497 (1326 bp)
Type: Others
Protein ID: WP_112741690.1
Location: 97642..98364 (723 bp)
Type: Others
Protein ID: WP_029103568.1
Location: 103556..103885 (330 bp)
Type: Others
Protein ID: WP_264676042.1
Location: 104008..104253 (246 bp)
Type: Others
Protein ID: WP_078274709.1
Location: 104540..104815 (276 bp)
Type: Others
Protein ID: WP_078274708.1
Location: 98404..98616 (213 bp)
Type: Others
Protein ID: WP_078274724.1
Location: 98732..99556 (825 bp)
Type: Others
Protein ID: WP_078274723.1
Location: 99606..99887 (282 bp)
Type: Antitoxin
Protein ID: WP_078274722.1
Location: 99877..100212 (336 bp)
Type: Toxin
Protein ID: WP_228157738.1
Location: 100276..101436 (1161 bp)
Type: Others
Protein ID: WP_078274721.1
Location: 101522..101815 (294 bp)
Type: Others
Protein ID: WP_078274720.1
Location: 101812..102687 (876 bp)
Type: Others
Protein ID: WP_162860331.1
Location: 103180..103437 (258 bp)
Type: Others
Protein ID: WP_112741693.1
Location: 104810..104965 (156 bp)
Type: Others
Protein ID: WP_158079680.1
Location: 105017..105151 (135 bp)
Type: Others
Protein ID: WP_264676041.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LP127_RS00460 (LP127_00465)95304..96062+759WP_078274726.1YciK family oxidoreductase-
LP127_RS00465 (LP127_00470)96172..97497+1326WP_112741690.1hemolysin family protein-
LP127_RS00470 (LP127_00475)97642..98364+723WP_029103568.1nitroreductase family protein-
LP127_RS00475 (LP127_00480)98404..98616-213WP_078274724.1hypothetical protein-
LP127_RS00480 (LP127_00485)98732..99556-825WP_078274723.1site-specific integrase-
LP127_RS00485 (LP127_00490)99606..99887-282WP_078274722.1NadS family proteinAntitoxin
LP127_RS00490 (LP127_00495)99877..100212-336WP_228157738.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LP127_RS00495 (LP127_00500)100276..101436-1161WP_078274721.1zonular occludens toxin domain-containing protein-
LP127_RS00500 (LP127_00505)101522..101815-294WP_078274720.1DUF2523 family protein-
LP127_RS00505 (LP127_00510)101812..102687-876WP_162860331.1virulence factor TspB C-terminal domain-related protein-
LP127_RS00510 (LP127_00515)103180..103437-258WP_112741693.1hypothetical protein-
LP127_RS00515 (LP127_00520)103556..103885+330WP_264676042.1hypothetical protein-
LP127_RS00520 (LP127_00525)104008..104253+246WP_078274709.1hypothetical protein-
LP127_RS00525 (LP127_00530)104540..104815+276WP_078274708.1hypothetical protein-
LP127_RS00530 (LP127_00535)104810..104965-156WP_158079680.1hypothetical protein-
LP127_RS00535105017..105151-135WP_264676041.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-84)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12636.69 Da        Isoelectric Point: 10.0972

>T226117 WP_228157738.1 NZ_CP087771:c100212-99877 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Download         Length: 336 bp

>T226117 NZ_CP122302:25126-25431 [Salmonella enterica]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10425.98 Da        Isoelectric Point: 10.0023

>AT226117 WP_078274722.1 NZ_CP087771:c99887-99606 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Download         Length: 282 bp

>AT226117 NZ_CP122302:24906-25124 [Salmonella enterica]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References