Detailed information of TA system TA226113

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1837713..1838311
• Replicon: chromosome
• Accession: NZ_CP087768
• Organism: Moraxella bovis strain SAM109245

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP116_RS09145
• Protein ID: WP_078275306.1
• Coordinates: 1837713..1837991 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: LP116_RS09150
• Protein ID: WP_078275307.1
• Coordinates: 1838006..1838311 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP116_RS09125 (LP116_09040)	1833190..1833549	-	360	WP_115368637.1	hypothetical protein	-
LP116_RS09130 (LP116_09045)	1833546..1836476	-	2931	WP_264684075.1	DUF1983 domain-containing protein	-
LP116_RS09135 (LP116_09050)	1836359..1837018	-	660	WP_264684076.1	hypothetical protein	-
LP116_RS09140 (LP116_09055)	1837043..1837627	-	585	WP_264676215.1	tail assembly protein	-
LP116_RS09145 (LP116_09060)	1837713..1837991	+	279	WP_078275306.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP116_RS09150 (LP116_09065)	1838006..1838311	+	306	WP_078275307.1	HigA family addiction module antitoxin	Antitoxin
LP116_RS09155 (LP116_09070)	1838283..1839059	-	777	WP_078275308.1	C40 family peptidase	-
LP116_RS09160 (LP116_09075)	1839127..1839315	-	189	WP_078275309.1	hypothetical protein	-
LP116_RS09165 (LP116_09080)	1839312..1839908	-	597	WP_264676214.1	antA/AntB antirepressor family protein	-
LP116_RS09170 (LP116_09085)	1840081..1840311	+	231	WP_078275311.1	Arc family DNA-binding protein	-
LP116_RS09175 (LP116_09090)	1840353..1841036	-	684	WP_264676213.1	phage minor tail protein L	-
LP116_RS09180 (LP116_09095)	1841033..1841422	-	390	WP_078275313.1	hypothetical protein	-
LP116_RS09185 (LP116_09100)	1841458..1841790	-	333	WP_078275314.1	phage tail protein	-
LP116_RS09190 (LP116_09105)	1841787..1841948	-	162	WP_158079719.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1829800..1877172	47372

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-95)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10491.92 Da
• Isoelectric Point: 5.0474

>T226113 WP_078275306.1 NZ_CP087768:1837713-1837991 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Nucleotide

• Length: 279 bp

>T226113 NZ_CP122301:c4072622-4072338 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11173.81 Da
• Isoelectric Point: 7.3174

>AT226113 WP_078275307.1 NZ_CP087768:1838006-1838311 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Nucleotide

• Length: 306 bp

>AT226113 NZ_CP122301:c4072854-4072612 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA