Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1837713..1838311 Replicon chromosome
Accession NZ_CP087768
Organism Moraxella bovis strain SAM109245

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP116_RS09145 Protein ID WP_078275306.1
Coordinates 1837713..1837991 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LP116_RS09150 Protein ID WP_078275307.1
Coordinates 1838006..1838311 (+) Length 102 a.a.

Genomic Context

LP116_RS09145LP116_RS09150LP116_RS09170LP116_RS09125LP116_RS09130LP116_RS09135LP116_RS09140LP116_RS09155LP116_RS09160LP116_RS09165LP116_RS09175LP116_RS09180LP116_RS09185LP116_RS09190
Location: 1837713..1837991 (279 bp)
Type: Toxin
Protein ID: WP_078275306.1
Location: 1838006..1838311 (306 bp)
Type: Antitoxin
Protein ID: WP_078275307.1
Location: 1840081..1840311 (231 bp)
Type: Others
Protein ID: WP_078275311.1
Location: 1833190..1833549 (360 bp)
Type: Others
Protein ID: WP_115368637.1
Location: 1833546..1836476 (2931 bp)
Type: Others
Protein ID: WP_264684075.1
Location: 1836359..1837018 (660 bp)
Type: Others
Protein ID: WP_264684076.1
Location: 1837043..1837627 (585 bp)
Type: Others
Protein ID: WP_264676215.1
Location: 1838283..1839059 (777 bp)
Type: Others
Protein ID: WP_078275308.1
Location: 1839127..1839315 (189 bp)
Type: Others
Protein ID: WP_078275309.1
Location: 1839312..1839908 (597 bp)
Type: Others
Protein ID: WP_264676214.1
Location: 1840353..1841036 (684 bp)
Type: Others
Protein ID: WP_264676213.1
Location: 1841033..1841422 (390 bp)
Type: Others
Protein ID: WP_078275313.1
Location: 1841458..1841790 (333 bp)
Type: Others
Protein ID: WP_078275314.1
Location: 1841787..1841948 (162 bp)
Type: Others
Protein ID: WP_158079719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LP116_RS09125 (LP116_09040)1833190..1833549-360WP_115368637.1hypothetical protein-
LP116_RS09130 (LP116_09045)1833546..1836476-2931WP_264684075.1DUF1983 domain-containing protein-
LP116_RS09135 (LP116_09050)1836359..1837018-660WP_264684076.1hypothetical protein-
LP116_RS09140 (LP116_09055)1837043..1837627-585WP_264676215.1tail assembly protein-
LP116_RS09145 (LP116_09060)1837713..1837991+279WP_078275306.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LP116_RS09150 (LP116_09065)1838006..1838311+306WP_078275307.1HigA family addiction module antitoxinAntitoxin
LP116_RS09155 (LP116_09070)1838283..1839059-777WP_078275308.1C40 family peptidase-
LP116_RS09160 (LP116_09075)1839127..1839315-189WP_078275309.1hypothetical protein-
LP116_RS09165 (LP116_09080)1839312..1839908-597WP_264676214.1antA/AntB antirepressor family protein-
LP116_RS09170 (LP116_09085)1840081..1840311+231WP_078275311.1Arc family DNA-binding protein-
LP116_RS09175 (LP116_09090)1840353..1841036-684WP_264676213.1phage minor tail protein L-
LP116_RS09180 (LP116_09095)1841033..1841422-390WP_078275313.1hypothetical protein-
LP116_RS09185 (LP116_09100)1841458..1841790-333WP_078275314.1phage tail protein-
LP116_RS09190 (LP116_09105)1841787..1841948-162WP_158079719.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1829800..187717247372


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226113 WP_078275306.1 NZ_CP087768:1837713-1837991 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226113 NZ_CP122301:c4072622-4072338 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11173.81 Da        Isoelectric Point: 7.3174

>AT226113 WP_078275307.1 NZ_CP087768:1838006-1838311 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Download         Length: 306 bp

>AT226113 NZ_CP122301:c4072854-4072612 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References