Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 180238..180844 Replicon chromosome
Accession NZ_CP087768
Organism Moraxella bovis strain SAM109245

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP116_RS00925 Protein ID WP_228157738.1
Coordinates 180509..180844 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LP116_RS00920 Protein ID WP_078274722.1
Coordinates 180238..180519 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP116_RS00895 (LP116_00895) 175936..176694 + 759 WP_078274726.1 YciK family oxidoreductase -
LP116_RS00900 (LP116_00900) 176804..178129 + 1326 WP_112741690.1 hemolysin family protein -
LP116_RS00905 (LP116_00905) 178274..178996 + 723 WP_029103568.1 nitroreductase family protein -
LP116_RS00910 (LP116_00910) 179036..179248 - 213 WP_078274724.1 hypothetical protein -
LP116_RS00915 (LP116_00915) 179364..180188 - 825 WP_078274723.1 site-specific integrase -
LP116_RS00920 (LP116_00920) 180238..180519 - 282 WP_078274722.1 NadS family protein Antitoxin
LP116_RS00925 (LP116_00925) 180509..180844 - 336 WP_228157738.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP116_RS00930 (LP116_00930) 180908..182068 - 1161 WP_078274721.1 zonular occludens toxin domain-containing protein -
LP116_RS00935 (LP116_00935) 182154..182447 - 294 WP_078274720.1 DUF2523 family protein -
LP116_RS00940 (LP116_00940) 182444..183076 - 633 WP_264684100.1 virulence factor TspB C-terminal domain-related protein -
LP116_RS00945 (LP116_00945) 183335..183580 + 246 WP_078274709.1 hypothetical protein -
LP116_RS00950 (LP116_00950) 183867..184142 + 276 WP_078274708.1 hypothetical protein -
LP116_RS00955 (LP116_00955) 184137..184292 - 156 WP_158079680.1 hypothetical protein -
LP116_RS00960 184344..184478 - 135 WP_264676041.1 hypothetical protein -
LP116_RS00965 (LP116_00960) 184466..184807 - 342 WP_228157741.1 hemerythrin domain-containing protein -
LP116_RS00970 (LP116_00965) 184981..185121 - 141 WP_029103571.1 type B 50S ribosomal protein L36 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-84)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12636.69 Da        Isoelectric Point: 10.0972

>T226107 WP_228157738.1 NZ_CP087768:c180844-180509 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Download         Length: 336 bp

>T226107 NZ_CP122301:c2443863-2443708 [Salmonella enterica]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10425.98 Da        Isoelectric Point: 10.0023

>AT226107 WP_078274722.1 NZ_CP087768:c180519-180238 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Download         Length: 282 bp

>AT226107 NZ_CP122301:2443875-2443933 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References