Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2026082..2026688 Replicon chromosome
Accession NZ_CP087765
Organism Moraxella bovis strain SAM109246

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP096_RS10365 Protein ID WP_228157738.1
Coordinates 2026082..2026417 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LP096_RS10370 Protein ID WP_078274722.1
Coordinates 2026407..2026688 (+) Length 94 a.a.

Genomic Context

LP096_RS10320LP096_RS10325LP096_RS10345LP096_RS10350LP096_RS10355LP096_RS10360LP096_RS10365LP096_RS10370LP096_RS10375LP096_RS10380LP096_RS10330LP096_RS10335LP096_RS10340LP096_RS10385LP096_RS10390LP096_RS10395
Location: 2021143..2021277 (135 bp)
Type: Others
Protein ID: WP_264676041.1
Location: 2021329..2021484 (156 bp)
Type: Others
Protein ID: WP_158079680.1
Location: 2022857..2023114 (258 bp)
Type: Others
Protein ID: WP_112741693.1
Location: 2023607..2024482 (876 bp)
Type: Others
Protein ID: WP_162860331.1
Location: 2024479..2024772 (294 bp)
Type: Others
Protein ID: WP_078274720.1
Location: 2024858..2026018 (1161 bp)
Type: Others
Protein ID: WP_078274721.1
Location: 2026082..2026417 (336 bp)
Type: Toxin
Protein ID: WP_228157738.1
Location: 2026407..2026688 (282 bp)
Type: Antitoxin
Protein ID: WP_078274722.1
Location: 2026738..2027562 (825 bp)
Type: Others
Protein ID: WP_078274723.1
Location: 2027678..2027890 (213 bp)
Type: Others
Protein ID: WP_078274724.1
Location: 2021479..2021754 (276 bp)
Type: Others
Protein ID: WP_078274708.1
Location: 2022041..2022286 (246 bp)
Type: Others
Protein ID: WP_078274709.1
Location: 2022409..2022738 (330 bp)
Type: Others
Protein ID: WP_264676042.1
Location: 2027930..2028652 (723 bp)
Type: Others
Protein ID: WP_029103568.1
Location: 2028797..2030122 (1326 bp)
Type: Others
Protein ID: WP_112741690.1
Location: 2030232..2030990 (759 bp)
Type: Others
Protein ID: WP_078274726.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LP096_RS103202021143..2021277+135WP_264676041.1hypothetical protein-
LP096_RS10325 (LP096_10185)2021329..2021484+156WP_158079680.1hypothetical protein-
LP096_RS10330 (LP096_10190)2021479..2021754-276WP_078274708.1hypothetical protein-
LP096_RS10335 (LP096_10195)2022041..2022286-246WP_078274709.1hypothetical protein-
LP096_RS10340 (LP096_10200)2022409..2022738-330WP_264676042.1hypothetical protein-
LP096_RS10345 (LP096_10205)2022857..2023114+258WP_112741693.1hypothetical protein-
LP096_RS10350 (LP096_10210)2023607..2024482+876WP_162860331.1virulence factor TspB C-terminal domain-related protein-
LP096_RS10355 (LP096_10215)2024479..2024772+294WP_078274720.1DUF2523 family protein-
LP096_RS10360 (LP096_10220)2024858..2026018+1161WP_078274721.1zonular occludens toxin domain-containing protein-
LP096_RS10365 (LP096_10225)2026082..2026417+336WP_228157738.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LP096_RS10370 (LP096_10230)2026407..2026688+282WP_078274722.1NadS family proteinAntitoxin
LP096_RS10375 (LP096_10235)2026738..2027562+825WP_078274723.1site-specific integrase-
LP096_RS10380 (LP096_10240)2027678..2027890+213WP_078274724.1hypothetical protein-
LP096_RS10385 (LP096_10245)2027930..2028652-723WP_029103568.1nitroreductase family protein-
LP096_RS10390 (LP096_10250)2028797..2030122-1326WP_112741690.1hemolysin family protein-
LP096_RS10395 (LP096_10255)2030232..2030990-759WP_078274726.1YciK family oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-84)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12636.69 Da        Isoelectric Point: 10.0972

>T226105 WP_228157738.1 NZ_CP087765:2026082-2026417 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Download         Length: 336 bp

>T226105 NZ_CP122301:836169-836567 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10425.98 Da        Isoelectric Point: 10.0023

>AT226105 WP_078274722.1 NZ_CP087765:2026407-2026688 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Download         Length: 282 bp

>AT226105 NZ_CP122301:835942-836169 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References