Detailed information of TA system TA226105

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2026082..2026688
• Replicon: chromosome
• Accession: NZ_CP087765
• Organism: Moraxella bovis strain SAM109246

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP096_RS10365
• Protein ID: WP_228157738.1
• Coordinates: 2026082..2026417 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LP096_RS10370
• Protein ID: WP_078274722.1
• Coordinates: 2026407..2026688 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP096_RS10320	2021143..2021277	+	135	WP_264676041.1	hypothetical protein	-
LP096_RS10325 (LP096_10185)	2021329..2021484	+	156	WP_158079680.1	hypothetical protein	-
LP096_RS10330 (LP096_10190)	2021479..2021754	-	276	WP_078274708.1	hypothetical protein	-
LP096_RS10335 (LP096_10195)	2022041..2022286	-	246	WP_078274709.1	hypothetical protein	-
LP096_RS10340 (LP096_10200)	2022409..2022738	-	330	WP_264676042.1	hypothetical protein	-
LP096_RS10345 (LP096_10205)	2022857..2023114	+	258	WP_112741693.1	hypothetical protein	-
LP096_RS10350 (LP096_10210)	2023607..2024482	+	876	WP_162860331.1	virulence factor TspB C-terminal domain-related protein	-
LP096_RS10355 (LP096_10215)	2024479..2024772	+	294	WP_078274720.1	DUF2523 family protein	-
LP096_RS10360 (LP096_10220)	2024858..2026018	+	1161	WP_078274721.1	zonular occludens toxin domain-containing protein	-
LP096_RS10365 (LP096_10225)	2026082..2026417	+	336	WP_228157738.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP096_RS10370 (LP096_10230)	2026407..2026688	+	282	WP_078274722.1	NadS family protein	Antitoxin
LP096_RS10375 (LP096_10235)	2026738..2027562	+	825	WP_078274723.1	site-specific integrase	-
LP096_RS10380 (LP096_10240)	2027678..2027890	+	213	WP_078274724.1	hypothetical protein	-
LP096_RS10385 (LP096_10245)	2027930..2028652	-	723	WP_029103568.1	nitroreductase family protein	-
LP096_RS10390 (LP096_10250)	2028797..2030122	-	1326	WP_112741690.1	hemolysin family protein	-
LP096_RS10395 (LP096_10255)	2030232..2030990	-	759	WP_078274726.1	YciK family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-84)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12636.69 Da
• Isoelectric Point: 10.0972

>T226105 WP_228157738.1 NZ_CP087765:2026082-2026417 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Nucleotide

• Length: 336 bp

>T226105 NZ_CP122301:836169-836567 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10425.98 Da
• Isoelectric Point: 10.0023

>AT226105 WP_078274722.1 NZ_CP087765:2026407-2026688 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Nucleotide

• Length: 282 bp

>AT226105 NZ_CP122301:835942-836169 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA