Detailed information of TA system TA226098

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 316837..317435
• Replicon: chromosome
• Accession: NZ_CP087765
• Organism: Moraxella bovis strain SAM109246

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP096_RS01825
• Protein ID: WP_078275306.1
• Coordinates: 317157..317435 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LP096_RS01820
• Protein ID: WP_276001721.1
• Coordinates: 316837..317127 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP096_RS01780 (LP096_01750)	312743..312943	-	201	WP_062501372.1	hypothetical protein	-
LP096_RS01785 (LP096_01755)	313322..313690	+	369	WP_264689325.1	phage tail protein	-
LP096_RS01790 (LP096_01760)	313726..314115	+	390	WP_078275313.1	hypothetical protein	-
LP096_RS01795 (LP096_01765)	314112..314795	+	684	WP_264676213.1	phage minor tail protein L	-
LP096_RS01800 (LP096_01770)	314837..315067	-	231	WP_078275311.1	Arc family DNA-binding protein	-
LP096_RS01805 (LP096_01775)	315240..315836	+	597	WP_264676214.1	antA/AntB antirepressor family protein	-
LP096_RS01810 (LP096_01780)	315833..316021	+	189	WP_078275309.1	hypothetical protein	-
LP096_RS01815 (LP096_01785)	316089..316865	+	777	WP_078275308.1	C40 family peptidase	-
LP096_RS01820 (LP096_01790)	316837..317127	-	291	WP_276001721.1	HigA family addiction module antitoxin	Antitoxin
LP096_RS01825 (LP096_01795)	317157..317435	-	279	WP_078275306.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP096_RS01830 (LP096_01800)	317521..318105	+	585	WP_264676215.1	tail assembly protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	285958..332849	46891

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-90)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10491.92 Da
• Isoelectric Point: 5.0474

>T226098 WP_078275306.1 NZ_CP087765:c317435-317157 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Nucleotide

• Length: 279 bp

>T226098 NZ_CP121861:2995874-2996620 [Bacillus stercoris]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATTGTGGCTGGACTGGGGTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGGAAAACATGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGATCGGTATCTTATTGTCGCAGTCAGCTTTGCTTTGATTGATGCTTTC
ATCTTCTTAAGTGCATACGTCAAAAAACTGGCTGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGCATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCAATATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAATGGTTCTCATCCCTTTTACCATCGAGACAAAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10596.11 Da
• Isoelectric Point: 6.7228

>AT226098 WP_276001721.1 NZ_CP087765:c317127-316837 [Moraxella bovis]
MRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELRLAETT
LGDSLDFISPHEVAHA

Nucleotide

• Length: 291 bp

>AT226098 NZ_CP121861:2996620-2996790 [Bacillus stercoris]
ATGGAACGTGCGTTTCAAAACGGATGCGAGCCCAGAGCGGCCAAACCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCACACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA