Detailed information of TA system TA226083

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 2933782..2934298
• Replicon: chromosome
• Accession: NZ_CP087711
• Organism: Plesiomonas shigelloides strain 7A

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: R8AQQ6
• Locus tag: LPH35_RS13010
• Protein ID: WP_010863491.1
• Coordinates: 2934029..2934298 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: LPH35_RS13005
• Protein ID: WP_230432216.1
• Coordinates: 2933782..2934036 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH35_RS12980	2930176..2930865	-	690	WP_230432207.1	DUF5677 domain-containing protein	-
LPH35_RS12985	2930868..2931329	-	462	WP_230432209.1	hypothetical protein	-
LPH35_RS12990	2931329..2932153	-	825	WP_230432211.1	AAA family ATPase	-
LPH35_RS12995	2932499..2932759	+	261	WP_230432212.1	hypothetical protein	-
LPH35_RS13000	2932864..2933394	-	531	WP_230432214.1	hypothetical protein	-
LPH35_RS13005	2933782..2934036	+	255	WP_230432216.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LPH35_RS13010	2934029..2934298	+	270	WP_010863491.1	Txe/YoeB family addiction module toxin	Toxin
LPH35_RS13015	2934554..2935156	-	603	WP_230432218.1	hypothetical protein	-
LPH35_RS13020	2935496..2935795	+	300	WP_116547297.1	DUF1778 domain-containing protein	-
LPH35_RS13025	2935795..2936292	+	498	WP_230432219.1	GNAT family N-acetyltransferase	-
LPH35_RS13030	2936465..2937028	-	564	WP_230432221.1	DUF922 domain-containing protein	-
LPH35_RS13035	2937524..2938141	+	618	WP_230432222.1	nucleotidyltransferase domain-containing protein	-
LPH35_RS13040	2938462..2939220	-	759	WP_230432224.1	DUF2971 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10689.14 Da
• Isoelectric Point: 6.9482

>T226083 WP_010863491.1 NZ_CP087711:2934029-2934298 [Plesiomonas shigelloides]
MSERLLCWTDESWDDYIYWQSQDKKTLKRINKLIIDVKRTPFEGIGKPEALRENLSGFWSRRIDDTNRLVYAVDDLSITI
ISCRYHYQA

Nucleotide

• Length: 270 bp

>T226083 NZ_CP121800:c1099950-1098634 [Aeromonas dhakensis]
ATGATGAATGGTTCTGAGCACCATCGGCTGGAACTTCGGCTGGGTAATCAGCTGATTGGCCATCTCGAATATGACTCCAA
CCGGGATTCGTTTCAGCTCGGCTATCTGCCAGAGTGGCAAGCGCGCGGATTCCCACTCTCACCGCCACTGGCGTTGGATG
GCTCGGCCAGCAGCGCTCAGATCCGGGCGTATCTCGGCAACTTACTGCCAGAAAATCGCGGGCTGGATCATCTGATTGAG
GTACTCTCCGTTTCGCGCAGCAATCTCTTTGCCCTAATCCACGGTATCGGCCGCGATGTATCCGGGGCTGTCACCTTCAC
CCTACCCGCAGAGCCCGACATTCCCACCCGGTTTCGCCCCATCACACCAGAGGAGTTGATGCTGCGCCTCGATCAACCCG
AGATTTGGCCGCTGGAAGTCTGGGATGGCCGCCCCCGACTCTCGGTTGCGGGTGTGCAGGCCAAACTCAACCTGCTGCGA
CTCGAGGGGAGGCTAGGATTTGGCGAAGGTGAACTCTGTTCAACCCACCTCCTCAAGTTCGAGCATCACCCTCATCTAGT
GATCAATGAATTTGTAACCATGCAGCTGGCCGCACAGCTTAGCATGCCGGTGGCGCGGGTCGAACTGCATACTGTGGGTC
AGGGTGAGAAGTCCCACAGAAGCTTGCTGGTGGAACGGTTCGACCGTCGTCTTGATGAGGATGGCATGAGGGTCCGCCGT
CGCCACATGATCGATGCCTGTCAGGGGCTGGGGTTCCCCGTCGCCCGAAAATATGAACGCAACTTCGGTGATGGTCGGGA
CGTGGCCCATATTCGGGAAGGGGTGAGCCTGCCACGGCTGTTCAGCCTTAGCGCTCTCTGCGTCAATCCAGCGCAGGCCA
GACTGGACATGCTGCAATGGCTGCTCTTCAACCTCTGCGTCAACAATCACGATGCCCACGGCAAGAACTACAGCTTCTTC
GTATCAAAAGCAGGGCTGACGCCCACCCCTTGGTACGATCTGGTCAATGTGGGGCTTTACCCCGAGTTCAACCAGCATCT
GGCCATGGCCATAGGCGACGAATTTGCTCCCGAGGCGATCAACGCATGGCAGTTGCTGGAAATGGCCGAGGCATGTGACC
TACCCGAACGCCTGCTGCAACAGACCTTGCAGAAGATAGCCAGCGACATCCTCCACCATTTGGATGCCGCTATAGCCATG
GTCGAGACAGACCATCCCGCCGAGCTGGATTATCTAGCACGCTATAAAGATGACGTTAAGCGCCGTTGCCACCATTTTCA
GGAGCAGGCGGGGCTGTTGCCCGAACTGCAGCTATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9482.64 Da
• Isoelectric Point: 5.6706

>AT226083 WP_230432216.1 NZ_CP087711:2933782-2934036 [Plesiomonas shigelloides]
MRIVSFTEARNSLKSVLDSVVNDADTTIITRRDADDAVVMSLDYYNSLMETVHLLRSPANAEHLNRSIAQFKAGRATQRE
LKDE

Nucleotide

• Length: 255 bp

>AT226083 NZ_CP121800:c1100227-1099934 [Aeromonas dhakensis]
ATGACAGATACACCGTTGCCAACCGGCACGAAAGAACTGGATCCCGCCTCGCTGGGACTGGCGATACGGGAGAGACGCAA
AGCAGCCAAGATGACCCAAGAGGTGACGGCCTCACTGTGCGGCATCTCCAAGAAAACCCTGATCAAGATTGAAAAAGGGG
GGGATGTCTACCTCTCGACCCTGCTGCAGGTGATGAAGGCGCTGGGACTGAGGTTGCAACTGGTGCAAGAAGCGGGATCA
CAGGTAATGAGCAGCTACAGCCAACCAGAGGTCGGTGATGATGAATGGTTCTGA

Structures

Toxin

• AlphaFold DB: R8AQQ6