Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 352534..353180 Replicon chromosome
Accession NZ_CP087706
Organism Klebsiella pneumoniae strain YZH2487

Toxin (Protein)


Gene name higB Uniprot ID A0A486LFK7
Locus tag LO768_RS01625 Protein ID WP_023301313.1
Coordinates 352534..352881 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag LO768_RS01630 Protein ID WP_002920557.1
Coordinates 352881..353180 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO768_RS01615 (348460) 348460..349893 + 1434 WP_002920564.1 glycogen synthase GlgA -
LO768_RS01620 (349911) 349911..352358 + 2448 WP_002920561.1 glycogen phosphorylase -
LO768_RS01625 (352534) 352534..352881 + 348 WP_023301313.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LO768_RS01630 (352881) 352881..353180 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
LO768_RS01635 (353243) 353243..354751 - 1509 WP_114263839.1 glycerol-3-phosphate dehydrogenase -
LO768_RS01640 (354956) 354956..355285 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
LO768_RS01645 (355336) 355336..356166 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
LO768_RS01650 (356216) 356216..356974 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13506.49 Da        Isoelectric Point: 6.2327

>T226061 WP_023301313.1 NZ_CP087706:352534-352881 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKETITMADREFSQHLTKER

Download         Length: 348 bp

>T226061 NZ_CP121768:c380991-380656 [Glaesserella parasuis]
ATGTCAGGAATTATCAACCAAATCGTCATTACAGATAATTTTTCAAAGTGGCTAGATGGTTTAAAAAATCCTATTGCTAA
AGCAACAGTGGCAAGAAGAATTAAGAATGCAGTAAAAGGTAATTTTGGTGATCATAAAGCGCTTGCAGGTACTGGTGGAC
TTTATGAAATGCGAATAGCGACAGGCGCTGGTTATCGAATTTACTATGCACAGCAGGGCGATGTTATTTATATTCTGTTA
CAAGGTGGTGATAAATCAACACAGCAAGCCGATATTGAGAAAGCGAAAGCATTGTGGGCAGAATTAAAACAGACAGGAGG
AAGTAATGAATATTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT226061 WP_002920557.1 NZ_CP087706:352881-353180 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT226061 NZ_CP121768:c380648-380352 [Glaesserella parasuis]
ATGGCAGAAAAACACGGTTTACGTCCTTTTGATGTCGCTGAATTTTTGGATAACGAAGAAACAATACAAGCCTATTTAGC
AGAAGTATTAAAAGAGGGCGATCAAGATGAGTTTTTGGAAGCCCTTAATGATGTAGCAAGAGCAAGGGGGATCGCAGAAC
TTGCGAAGCAAACGGGGTTAGGTAGAGAAAGTTTATATAAAACCCTATCTAAAGGAAGTAAACCTCGTTTTGAAACTATT
CAAAAAATTTTAGGAGCATTTAATCTTGTGCTTATCCCACAAATAAAAAATAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486LFK7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References