Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 498073..498648 Replicon chromosome
Accession NZ_CP087705
Organism Halopseudomonas aestusnigri strain GOM5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LO767_RS02305 Protein ID WP_088274748.1
Coordinates 498370..498648 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LO767_RS02300 Protein ID WP_088274746.1
Coordinates 498073..498357 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO767_RS02275 (LO767_02275) 493181..494488 - 1308 WP_172415953.1 TolC family protein -
LO767_RS02280 (LO767_02280) 494552..494899 - 348 WP_228247711.1 hypothetical protein -
LO767_RS02285 (LO767_02285) 495006..495263 + 258 Protein_451 mercuric reductase -
LO767_RS02290 (LO767_02290) 495279..496235 - 957 WP_042924031.1 bile acid:sodium symporter -
LO767_RS02295 (LO767_02295) 496768..497973 + 1206 WP_233048332.1 ISL3 family transposase -
LO767_RS02300 (LO767_02300) 498073..498357 - 285 WP_088274746.1 HigA family addiction module antitoxin Antitoxin
LO767_RS02305 (LO767_02305) 498370..498648 - 279 WP_088274748.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LO767_RS02310 (LO767_02310) 498870..499886 + 1017 WP_233049041.1 IS30 family transposase -
LO767_RS02315 (LO767_02315) 500047..501339 - 1293 WP_233049042.1 MgtC/SapB family protein -
LO767_RS02320 (LO767_02320) 501632..501940 + 309 WP_228247739.1 hypothetical protein -
LO767_RS02325 (LO767_02325) 501934..503616 + 1683 WP_228247740.1 PepSY-associated TM helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 486479..498648 12169
- flank IS/Tn - - 498870..499886 1016


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10345.86 Da        Isoelectric Point: 9.4837

>T226058 WP_088274748.1 NZ_CP087705:c498648-498370 [Halopseudomonas aestusnigri]
MITGFQHKGLEAFYKTGTTRGIQAAHAAKLSRILALLDVAAGPDDLNIPSFKLHQLKGELNGYWSIRVNGNWRVTFRFIG
VDVELVNYVDYH

Download         Length: 279 bp

>T226058 NZ_CP121766:c6487283-6487002 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTGGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10222.96 Da        Isoelectric Point: 8.7598

>AT226058 WP_088274746.1 NZ_CP087705:c498357-498073 [Halopseudomonas aestusnigri]
MMMNPPHPGELLREDVIAELGLSVKETAERLGMSRVALSRVLNGRAAISPDLALRLEMAGVSTARAWLAMQVNYDLAQAR
QHPQPPIKALQPVG

Download         Length: 285 bp

>AT226058 NZ_CP121766:c6487507-6487280 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAGCACGCCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References