Detailed information of TA system TA226052

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 38243..38775
• Replicon: chromosome
• Accession: NZ_CP087696
• Organism: Xylella taiwanensis strain PLS16B

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: Z9JHK5
• Locus tag: LPH57_RS00225
• Protein ID: WP_038272512.1
• Coordinates: 38243..38515 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Z9JHR3
• Locus tag: LPH57_RS00230
• Protein ID: WP_038272513.1
• Coordinates: 38515..38775 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH57_RS00175 (LPH57_00175)	34480..34716	-	237	WP_230428212.1	major capsid protein	-
LPH57_RS00180 (LPH57_00180)	34725..34931	-	207	WP_038273075.1	hypothetical protein	-
LPH57_RS00185 (LPH57_00185)	34934..35248	-	315	WP_230428211.1	hypothetical protein	-
LPH57_RS00190 (LPH57_00190)	35524..36111	-	588	WP_038273076.1	hypothetical protein	-
LPH57_RS00195 (LPH57_00195)	36308..36451	-	144	WP_160165233.1	hypothetical protein	-
LPH57_RS00200 (LPH57_00200)	36571..36771	-	201	WP_038273077.1	hypothetical protein	-
LPH57_RS00205 (LPH57_00205)	36820..37083	-	264	WP_162814095.1	hypothetical protein	-
LPH57_RS00210 (LPH57_00210)	37087..37248	-	162	WP_160165182.1	hypothetical protein	-
LPH57_RS00215 (LPH57_00215)	37337..37804	+	468	WP_162814096.1	DUF3693 domain-containing protein	-
LPH57_RS00220 (LPH57_00220)	37863..38207	+	345	WP_038272511.1	DUF3653 domain-containing protein	-
LPH57_RS00225 (LPH57_00225)	38243..38515	-	273	WP_038272512.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LPH57_RS00230 (LPH57_00230)	38515..38775	-	261	WP_038272513.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LPH57_RS00235 (LPH57_00235)	38864..39991	-	1128	WP_114867127.1	zonular occludens toxin domain-containing protein	-
LPH57_RS00240 (LPH57_00240)	40004..40348	-	345	WP_038273069.1	DUF2523 family protein	-
LPH57_RS00245 (LPH57_00245)	40351..41736	-	1386	WP_230428213.1	furin-like repeat-containing protein	-
LPH57_RS00250 (LPH57_00250)	41916..42152	-	237	WP_230428212.1	major capsid protein	-
LPH57_RS00255 (LPH57_00255)	42161..42367	-	207	WP_038273075.1	hypothetical protein	-
LPH57_RS00260 (LPH57_00260)	42370..42684	-	315	WP_230428211.1	hypothetical protein	-
LPH57_RS00265 (LPH57_00265)	42960..43547	-	588	WP_038273076.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	28063..54115	26052

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10638.26 Da
• Isoelectric Point: 9.9110

>T226052 WP_038272512.1 NZ_CP087696:c38515-38243 [Xylella taiwanensis]
MRRPAYSSQFKRDVRVSQKRGKDIEKLKILITLLIEGSPLPAMYLDHPLKGQWRSFRDAHVEPDWLLIYKVDGDVVRFER
TGRHADLFDD

Nucleotide

• Length: 273 bp

>T226052 NZ_CP121766:1195201-1195788 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCTCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9440.91 Da
• Isoelectric Point: 4.8047

>AT226052 WP_038272513.1 NZ_CP087696:c38775-38515 [Xylella taiwanensis]
MAANALVRARVDEALKDEAASVLATMGLTVSDLIRITLTKVAREKMLPFEMHSPNRLTVETFVKSECGEDVHYAESADAM
FKDLGI

Nucleotide

• Length: 261 bp

>AT226052 NZ_CP121766:1195855-1196709 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAGCAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Structures

Toxin

• AlphaFold DB: Z9JHK5

Antitoxin

• AlphaFold DB: Z9JHR3