Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2312977..2313558 Replicon chromosome
Accession NZ_CP087694
Organism Xylella taiwanensis strain PLS433

Toxin (Protein)


Gene name graT Uniprot ID Z9JLS9
Locus tag LPH46_RS09580 Protein ID WP_038270683.1
Coordinates 2312977..2313255 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LPH46_RS09585 Protein ID WP_081755408.1
Coordinates 2313259..2313558 (+) Length 100 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPH46_RS09545 (LPH46_09545) 2308258..2309304 + 1047 WP_038270717.1 sulfate/molybdate ABC transporter ATP-binding protein -
LPH46_RS09550 (LPH46_09550) 2309991..2310587 - 597 WP_162814073.1 contractile injection system protein, VgrG/Pvc8 family -
LPH46_RS09555 (LPH46_09555) 2310775..2310855 - 81 Protein_1882 tail protein X -
LPH46_RS09560 (LPH46_09560) 2310852..2311106 - 255 WP_230428278.1 phage tail protein -
LPH46_RS09565 (LPH46_09565) 2311179..2311661 - 483 Protein_1884 phage tail protein I -
LPH46_RS09570 (LPH46_09570) 2311654..2312547 - 894 WP_038270682.1 baseplate J/gp47 family protein -
LPH46_RS09575 (LPH46_09575) 2312547..2312876 - 330 WP_230428175.1 GPW/gp25 family protein -
LPH46_RS09580 (LPH46_09580) 2312977..2313255 + 279 WP_038270683.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LPH46_RS09585 (LPH46_09585) 2313259..2313558 + 300 WP_081755408.1 HigA family addiction module antitoxin Antitoxin
LPH46_RS09590 (LPH46_09590) 2313568..2313864 - 297 WP_230428176.1 phage baseplate assembly protein V -
LPH46_RS09595 (LPH46_09595) 2313818..2314027 - 210 WP_230428177.1 phage baseplate assembly protein V -
LPH46_RS09600 (LPH46_09600) 2314027..2314680 - 654 WP_230428178.1 hypothetical protein -
LPH46_RS09605 (LPH46_09605) 2314656..2315072 - 417 WP_230428499.1 hypothetical protein -
LPH46_RS09610 (LPH46_09610) 2315195..2315488 - 294 WP_038270685.1 hypothetical protein -
LPH46_RS09615 (LPH46_09615) 2315469..2315699 - 231 WP_230428500.1 hypothetical protein -
LPH46_RS09620 (LPH46_09620) 2315826..2316074 - 249 WP_038270686.1 hypothetical protein -
LPH46_RS09625 (LPH46_09625) 2316113..2317497 - 1385 Protein_1896 phage major capsid protein -
LPH46_RS09630 (LPH46_09630) 2317596..2318045 - 450 WP_230428180.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2308210..2334829 26619


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-92)

Antitoxin

(13-68)


Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10669.11 Da        Isoelectric Point: 9.0910

>T226043 WP_038270683.1 NZ_CP087694:2312977-2313255 [Xylella taiwanensis]
MIKTFADQDTESLFNGSRVRRFIHIEAVARRKLIQLHAAATLSFLNAPPGNRLETLKGDRQGQHSIRINNQFRLCFIWEN
GDAYQVEIVDYH

Download         Length: 279 bp

>T226043 NZ_CP121700:1035066-1035479 [Methylobacterium indicum]
GTGAAGCCTCGCTACCTGCTCGATACGAACGTCATCATCGCGCTCCGGCGCAGGCGGCCACGCTCGGTCGTCGCTCGGTT
GACTGCACTCCGCATCGGCGAAGCCGTCATGTCGCCCGTGACTTACGGGGAGCTGTGCTTTGGGGCGGAGAAGAGCGTGG
ATCGGGACAATGCCTTCGCGGTCCTCGCCCGGCTGGTCGCCGTCGTTCCGATCGAGATCCCCGAGCCTGGGGAAACCGGC
CGCCGCTATGGTGAAATCCGGGCCACGCTCGGACGACAGGGGCAGTTGATCGGCAACAACGATGTCTGGATCGCCGCGCA
TGCGCTCGCGGCGAACCTCACGCTCGTGACCGGCAATGTCGGTGAGTTCAGCCGCGTGCCCGGTCTCGTCATCGAGGATT
GGACGGCCCATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10980.69 Da        Isoelectric Point: 9.0879

>AT226043 WP_081755408.1 NZ_CP087694:2313259-2313558 [Xylella taiwanensis]
MSMSKTLPPIHPGEILREEFMAPLGLSSNALAKAIGVTAARINEIVRERRGITADTALRLARYFGTDPQSWLNLEQHYAL
ECAKRDLGEALSRIHPRVA

Download         Length: 300 bp

>AT226043 NZ_CP121700:1034842-1035069 [Methylobacterium indicum]
ATGACTGTCGCCAAGCTTTTCATGTCCGGAGGCAGCCAAGCCGTCAGACTGCCGCGAGAATTCCGCTTCGACGGCAGCGA
GGTCGAGATTTTTCGCCGTGGCGACGAAGTCGTCCTGCGCGAGCGCCCGGCCAATCTCTCCGTGCTCCTCGACATCATCG
ACGACATGCCCGCCGACATGCTGACCGATCTGCATGATGGCCCGCCGCAGGAGCGCGAGGGCCTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Z9JLS9


Antitoxin

Source ID Structure

References