Detailed information of TA system TA226034

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 38344..38876
• Replicon: chromosome
• Accession: NZ_CP087693
• Organism: Xylella taiwanensis strain PLS429

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: Z9JHK5
• Locus tag: LPH62_RS00220
• Protein ID: WP_038272512.1
• Coordinates: 38344..38616 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Z9JHR3
• Locus tag: LPH62_RS00225
• Protein ID: WP_038272513.1
• Coordinates: 38616..38876 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH62_RS00195 (LPH62_00195)	33726..34937	-	1212	WP_038272508.1	signal recognition particle-docking protein FtsY	-
LPH62_RS00200 (LPH62_00200)	35782..36255	+	474	WP_038272510.1	LEA type 2 family protein	-
LPH62_RS00205 (LPH62_00205)	36531..37145	+	615	WP_081755477.1	HNH endonuclease	-
LPH62_RS00210 (LPH62_00210)	37642..37905	+	264	WP_268746652.1	DUF3693 domain-containing protein	-
LPH62_RS00215 (LPH62_00215)	37964..38308	+	345	WP_038272511.1	DUF3653 domain-containing protein	-
LPH62_RS00220 (LPH62_00220)	38344..38616	-	273	WP_038272512.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LPH62_RS00225 (LPH62_00225)	38616..38876	-	261	WP_038272513.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LPH62_RS00230 (LPH62_00230)	38965..40092	-	1128	WP_114867127.1	zonular occludens toxin domain-containing protein	-
LPH62_RS00235 (LPH62_00235)	40105..40449	-	345	WP_038273069.1	DUF2523 family protein	-
LPH62_RS00240 (LPH62_00240)	40452..41837	-	1386	WP_230428213.1	furin-like repeat-containing protein	-
LPH62_RS00245 (LPH62_00245)	42017..42253	-	237	WP_230428212.1	major capsid protein	-
LPH62_RS00250 (LPH62_00250)	42262..42468	-	207	WP_038273075.1	hypothetical protein	-
LPH62_RS00255 (LPH62_00255)	42471..42785	-	315	WP_230428211.1	hypothetical protein	-
LPH62_RS00260 (LPH62_00260)	43061..43648	-	588	WP_038273076.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	35782..58350	22568

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10638.26 Da
• Isoelectric Point: 9.9110

>T226034 WP_038272512.1 NZ_CP087693:c38616-38344 [Xylella taiwanensis]
MRRPAYSSQFKRDVRVSQKRGKDIEKLKILITLLIEGSPLPAMYLDHPLKGQWRSFRDAHVEPDWLLIYKVDGDVVRFER
TGRHADLFDD

Nucleotide

• Length: 273 bp

>T226034 NZ_CP121682:4877173-4877541 [Streptomyces sp. HUAS 5]
ATGCACTACCTCACGCTGCCCGAGTTGCTGAACCTCGCGAAGCGGCTCGGGGAGGACGCGGTGCGCGATTACGGGTTGCT
GGACTCGGCGCTGGCGCGTCCGCAGTCGAGTGTGTTCGGCCAGGACGCCTATCCGGACGTATGGCAGAAGGCCGCGGCGC
TGATGGAGTCCCTCGCGCGCAACCACGCTCTCGTCGACGGGAACAAGCGCCTCGCCTGGTACGCGACCTGGGTCTTCTTG
CACATGAACGGGCACGCGCTGGATCCGGACTTCGATGTGGACGAAGCGGAGAGGTTTGTCCTGGACGTATGCCAGGGCGC
ACTGGACGTGCCCAAGATCGCGTCCCAGCTGCCGCGTTTCGCGCGCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9440.91 Da
• Isoelectric Point: 4.8047

>AT226034 WP_038272513.1 NZ_CP087693:c38876-38616 [Xylella taiwanensis]
MAANALVRARVDEALKDEAASVLATMGLTVSDLIRITLTKVAREKMLPFEMHSPNRLTVETFVKSECGEDVHYAESADAM
FKDLGI

Nucleotide

• Length: 261 bp

>AT226034 NZ_CP121682:4876976-4877173 [Streptomyces sp. HUAS 5]
ATGGCTGGACTGAATCTGCGGTTTACCGACGAAGAGCTCGACGCCCTGCGTGAGCGTGCGGCTGCGGAGGGGCGCAGCAT
GCAGGCCTTCGCGCACGACGCGGTGGTCGCGGCCATAAACGAGCATTCGAGGCTGTTCAACGAGGCGGCCGAGCACGTGC
TGAAAGCCAGTGCGGAGCTCAACCGGAGGCTCGCCTGA

Structures

Toxin

• AlphaFold DB: Z9JHK5

Antitoxin

• AlphaFold DB: Z9JHR3