Detailed information of TA system TA226010

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 30800..31332
• Replicon: chromosome
• Accession: NZ_CP087689
• Organism: Xylella taiwanensis strain PLS415

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: Z9JHK5
• Locus tag: LPH50_RS00145
• Protein ID: WP_038272512.1
• Coordinates: 30800..31072 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Z9JHR3
• Locus tag: LPH50_RS00150
• Protein ID: WP_038272513.1
• Coordinates: 31072..31332 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH50_RS00130 (LPH50_00130)	27428..29503	+	2076	WP_230428285.1	S46 family peptidase	-
LPH50_RS00135 (LPH50_00135)	29610..30254	+	645	WP_038272466.1	histidine phosphatase family protein	-
LPH50_RS00140 (LPH50_00140)	30420..30764	+	345	WP_038272511.1	DUF3653 domain-containing protein	-
LPH50_RS00145 (LPH50_00145)	30800..31072	-	273	WP_038272512.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LPH50_RS00150 (LPH50_00150)	31072..31332	-	261	WP_038272513.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LPH50_RS00155 (LPH50_00155)	31421..32548	-	1128	WP_114867127.1	zonular occludens toxin domain-containing protein	-
LPH50_RS00160 (LPH50_00160)	32561..32905	-	345	WP_038273069.1	DUF2523 family protein	-
LPH50_RS00165 (LPH50_00165)	32908..34293	-	1386	WP_230428213.1	furin-like repeat-containing protein	-
LPH50_RS00170 (LPH50_00170)	34473..34709	-	237	WP_230428212.1	major capsid protein	-
LPH50_RS00175 (LPH50_00175)	34718..34924	-	207	WP_038273075.1	hypothetical protein	-
LPH50_RS00180 (LPH50_00180)	34927..35241	-	315	WP_230428211.1	hypothetical protein	-
LPH50_RS00185 (LPH50_00185)	35517..36104	-	588	WP_038273076.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	30420..50806	20386

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10638.26 Da
• Isoelectric Point: 9.9110

>T226010 WP_038272512.1 NZ_CP087689:c31072-30800 [Xylella taiwanensis]
MRRPAYSSQFKRDVRVSQKRGKDIEKLKILITLLIEGSPLPAMYLDHPLKGQWRSFRDAHVEPDWLLIYKVDGDVVRFER
TGRHADLFDD

Nucleotide

• Length: 273 bp

>T226010 NZ_CP121660:c632701-632318 [Sinorhizobium terangae]
GTGATCCTTGCCGACACTTCAATCTGGATTGATCATTTCCGGCATACCGATCCCGAACTGCGTAAGATTATTGAGGAAGA
TCGTCTCCTCTGCCATCCGGCCGTGATCGGAGAGCTCGCACTTGGCAGCCTTAGGGATCGCACCAGCGTGATAGCATTCC
TGACGGCTCAGCGCGAAGCGCTCGTCGCAACGCACGACGAAGTCGTGATGATGATAGATCGCCACGCTATTTTTAGCATG
GGCATTGGCTACACGGATGCCCATTTGCTGGCTTCGGTTCTCCTCGATCAGCGAGTGGTTTTGTGGACCAGAGCCAAGCG
TTTGCGGGCAGCGGCAGAAAAGGCGGGGGCGTCGCTGCACACCCCTGCTCATGCGGGGAACTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9440.91 Da
• Isoelectric Point: 4.8047

>AT226010 WP_038272513.1 NZ_CP087689:c31332-31072 [Xylella taiwanensis]
MAANALVRARVDEALKDEAASVLATMGLTVSDLIRITLTKVAREKMLPFEMHSPNRLTVETFVKSECGEDVHYAESADAM
FKDLGI

Nucleotide

• Length: 261 bp

>AT226010 NZ_CP121660:c632898-632698 [Sinorhizobium terangae]
ATGCGATCGACTATCAACCTCGACGACACTCTCGTGGAAAGGGCTAAGTCCCTAACCGGCACGAAGGAAACCGCCGCTCT
GGTCCGCCAGGCATTAGAGACGCTTGTTCGTGTGGAGTCAGGAAAACGCCTCATCGCGCTCGGAGGAACGATGCCGGATG
CGGAGGCCGCTCCACGCCGCCGGAGCCCAGCTGCCAAGTGA

Structures

Toxin

• AlphaFold DB: Z9JHK5

Antitoxin

• AlphaFold DB: Z9JHR3