Detailed information of TA system TA226005

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 30845..31377
• Replicon: chromosome
• Accession: NZ_CP087688
• Organism: Xylella taiwanensis strain PLS413

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: Z9JHK5
• Locus tag: LPH64_RS00145
• Protein ID: WP_038272512.1
• Coordinates: 30845..31117 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Z9JHR3
• Locus tag: LPH64_RS00150
• Protein ID: WP_038272513.1
• Coordinates: 31117..31377 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH64_RS00130 (LPH64_00130)	27473..29548	+	2076	WP_230428285.1	S46 family peptidase	-
LPH64_RS00135 (LPH64_00135)	29655..30299	+	645	WP_038272466.1	histidine phosphatase family protein	-
LPH64_RS00140 (LPH64_00140)	30465..30809	+	345	WP_038272511.1	DUF3653 domain-containing protein	-
LPH64_RS00145 (LPH64_00145)	30845..31117	-	273	WP_038272512.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LPH64_RS00150 (LPH64_00150)	31117..31377	-	261	WP_038272513.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LPH64_RS00155 (LPH64_00155)	31466..32593	-	1128	WP_114867127.1	zonular occludens toxin domain-containing protein	-
LPH64_RS00160 (LPH64_00160)	32606..32950	-	345	WP_038273069.1	DUF2523 family protein	-
LPH64_RS00165 (LPH64_00165)	32953..34338	-	1386	WP_230428213.1	furin-like repeat-containing protein	-
LPH64_RS00170 (LPH64_00170)	34518..34754	-	237	WP_230428212.1	major capsid protein	-
LPH64_RS00175 (LPH64_00175)	34763..34969	-	207	WP_038273075.1	hypothetical protein	-
LPH64_RS00180 (LPH64_00180)	34972..35286	-	315	WP_230428211.1	hypothetical protein	-
LPH64_RS00185 (LPH64_00185)	35562..36149	-	588	WP_038273076.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	30465..49342	18877

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10638.26 Da
• Isoelectric Point: 9.9110

>T226005 WP_038272512.1 NZ_CP087688:c31117-30845 [Xylella taiwanensis]
MRRPAYSSQFKRDVRVSQKRGKDIEKLKILITLLIEGSPLPAMYLDHPLKGQWRSFRDAHVEPDWLLIYKVDGDVVRFER
TGRHADLFDD

Nucleotide

• Length: 273 bp

>T226005 NZ_CP121656:c10391-10005 [Rhizobium sp. CB3171]
ATGGTCATCGACACTTCCGCCATCGTCGCCATGCTGCGCAATGAACCGGAGATGGAGCGACTGGAAAAGGCCCTGGTTGC
CGATCCGATCCGCCTCGTCCCCGCCACCTGCGTGCTGGAAGCGCGTATGGTGCTGGTCAGCCGCCGCGGCGAGCATGCGC
TGGCCGAAATCGATCTGTGGCTTTCGAAAATCAAGGCCGAGATCATTCCGGTCGATGCCGATCTGGTGGATCTGGCCACC
CAGGCTTGGCTGACCTACGGCAAGGGTCGCCATCCGGCCGGCTTGAATTTTGCCGACTGTTTTTCCTATGCCTTGGCCAA
ACGCGCCGACGAAGCGCTGCTGTTTATCGGCCAGGATTTTGCCCAGACCGATATCGAGGCGGCGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9440.91 Da
• Isoelectric Point: 4.8047

>AT226005 WP_038272513.1 NZ_CP087688:c31377-31117 [Xylella taiwanensis]
MAANALVRARVDEALKDEAASVLATMGLTVSDLIRITLTKVAREKMLPFEMHSPNRLTVETFVKSECGEDVHYAESADAM
FKDLGI

Nucleotide

• Length: 261 bp

>AT226005 NZ_CP121656:c10648-10391 [Rhizobium sp. CB3171]
GTGTCCCTGAACATCAAAAACCCGGCCACCGTTGCGCTCGTCGACGAACTGGCGCGGCGCCAGGGGATCAGCAAAACGGC
CGCCATTCATCAGGCGCTCAGCGAACAGCTCCGCCGCATGGGACACGGCGGCGGCGCTCAGGAGCGATTGCTGCATGAGC
TTCAAGCGATCCGTCAAAGAGTAGCACATCTTCCGGAATTGGACAGCCGCAGCGACGAGGATATCGTCGGCTATGACGAA
GATGGTATCCCCAACTGA

Structures

Toxin

• AlphaFold DB: Z9JHK5

Antitoxin

• AlphaFold DB: Z9JHR3