226001

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2274966..2275547 Replicon chromosome
Accession NZ_CP087686
Organism Xylella taiwanensis strain PLS19A

Toxin (Protein)


Gene name graT Uniprot ID Z9JLS9
Locus tag LPH61_RS09385 Protein ID WP_038270683.1
Coordinates 2274966..2275244 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LPH61_RS09390 Protein ID WP_081755408.1
Coordinates 2275248..2275547 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPH61_RS09350 (LPH61_09350) 2270247..2271293 + 1047 WP_038270717.1 sulfate/molybdate ABC transporter ATP-binding protein -
LPH61_RS09355 (LPH61_09355) 2271980..2272576 - 597 WP_162814073.1 contractile injection system protein, VgrG/Pvc8 family -
LPH61_RS09360 (LPH61_09360) 2272788..2272844 - 57 Protein_1844 phage tail protein -
LPH61_RS09365 (LPH61_09365) 2272841..2273095 - 255 WP_230428278.1 phage tail protein -
LPH61_RS09370 (LPH61_09370) 2273168..2273572 - 405 Protein_1846 phage tail protein I -
LPH61_RS09375 (LPH61_09375) 2273643..2274536 - 894 WP_038270682.1 baseplate J/gp47 family protein -
LPH61_RS09380 (LPH61_09380) 2274536..2274865 - 330 WP_230428175.1 GPW/gp25 family protein -
LPH61_RS09385 (LPH61_09385) 2274966..2275244 + 279 WP_038270683.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LPH61_RS09390 (LPH61_09390) 2275248..2275547 + 300 WP_081755408.1 HigA family addiction module antitoxin Antitoxin
LPH61_RS09395 (LPH61_09395) 2275557..2275853 - 297 WP_230428176.1 phage baseplate assembly protein V -
LPH61_RS09400 (LPH61_09400) 2275807..2276016 - 210 WP_230428177.1 phage baseplate assembly protein V -
LPH61_RS09405 (LPH61_09405) 2276016..2276669 - 654 WP_230428178.1 hypothetical protein -
LPH61_RS09410 (LPH61_09410) 2276645..2277094 - 450 WP_230428179.1 hypothetical protein -
LPH61_RS09415 (LPH61_09415) 2277184..2277477 - 294 WP_038270685.1 hypothetical protein -
LPH61_RS09420 (LPH61_09420) 2277815..2278063 - 249 WP_038270686.1 hypothetical protein -
LPH61_RS09425 (LPH61_09425) 2278102..2279486 - 1385 Protein_1857 phage major capsid protein -
LPH61_RS09430 (LPH61_09430) 2279585..2280034 - 450 WP_230428180.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2270199..2296818 26619


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-68)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10669.11 Da        Isoelectric Point: 9.0910

>T226001 WP_038270683.1 NZ_CP087686:2274966-2275244 [Xylella taiwanensis]
MIKTFADQDTESLFNGSRVRRFIHIEAVARRKLIQLHAAATLSFLNAPPGNRLETLKGDRQGQHSIRINNQFRLCFIWEN
GDAYQVEIVDYH

Download         Length: 279 bp

>T226001 NZ_CP121654:31849-32769 [Rhizobium sp. CB3171]
ATGCCGCGTGAGCCTCGCAACATCGGCGCATCAGTGCGAGCGCGGCTCCTCGATCGAGCACGTGCCGAGCGATCGGATTT
CCAGATTCTCCTGACGCGATATGCGCTCGAGCGTCTGCTCTACCGGCTAAGCGCGTCGCCGCACCGCGACCGCTTCATCC
TCAAAGGTGCGATGCTCTTCGTGACCTGGGTCGCCGATCCGTTTCGGCCTACACGCGATCTGGACCTGCTTGGCCACGGC
GACGGCGATGCCGGGGCGATTGCCGAAACCTTCCGGGCCATTTGCGCGCAGCCGGTCACCGATGACGGTGTTAGGTTTGA
TGTTGCCGCGCTGATCGCGGCTCCGATCCGTGAGGAGGTGGAATATGGTGGCGTGCGGGTTCGCACAACCGCAACTATCG
CCGGGGCGCGTATTCCGATCCAGGTCGACATTGGTTTCGGCGACGCCATTACACCCGCGGCCGTCGAGATCGACTATCCC
ACCCTGCTGGACGCCCCAACGCCGCGCCTTCGCGCATATCCGGTCGAAACTGTGGTGGCTGAGAAATTCGAAGCGCTCGT
AACGCTCGGCGTGGCCAATAGCCGGCTCAAGGACTTCTATGATCTCTGGGTGATTTCCCGAACATTCGGGCTTCGCCAGG
CCGCTCTTGTCGAGGCCGTCCAGCGTACTTTCGAACGACGCGGAACGGCTCTTCCATCCGATATTCCAGTTGGCCTGACC
GACGAATTCGCGGAGGCATGGGCCGCTCGATGGCGCGCCTTTCTCGGCCGCGATCGGATGGTCGCCGCACCTGATGCTTT
CGCCGTTACCATCGCCGATCTTCGCGTCTTCCTGATACCGCTGGTCGTCGGATTGAAGGAAGAACGAGTCTGGCCGCCGA
GCGGGCCCTGGTCGCCGGGAGCAGCAATCGATGAGGCATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10980.69 Da        Isoelectric Point: 9.0879

>AT226001 WP_081755408.1 NZ_CP087686:2275248-2275547 [Xylella taiwanensis]
MSMSKTLPPIHPGEILREEFMAPLGLSSNALAKAIGVTAARINEIVRERRGITADTALRLARYFGTDPQSWLNLEQHYAL
ECAKRDLGEALSRIHPRVA

Download         Length: 300 bp

>AT226001 NZ_CP121654:31239-31859 [Rhizobium sp. CB3171]
ATGTCATCCAAAAGCGACCAGCGGCTCCGTGCACTGAAACTCCTAGAAGCCCGGGGCATGCTCCGGCTGAAGGAGTTCGT
TGCCGAAGGCATCGGCCCGGAGACGCTTGCGCGCCTTGTCCGGGAGGAGGCGGTCATCCGCCCGGCACGTGGCCTCTATC
AACTCCCCGACGCACACGTCGAGGCTGCTCATACGCTGGCTGAGGCGGCGGTTCTGGTTCCGAAGGGTGTGGTCTGCCTA
ACCTCAGCCCTCCAATACCACGAACTGACGCTGCAGATGCCGTCGGCTGTATGGATGGCGATCGACCGTGCCGCCTGGCG
GCCCAAGATCGATTATCCCCCTATTCGGTTCGTGCGCTTCACTGGGTCGGCACTGACCGAAGGGGTCGAGCGTCACCGCA
TCGAGAATGTCGACGTTCCCATCACGGATCCGGCGAGGACAATTGTCGATTGCTTTCGCTACCGGACGAAGATCGGCCTC
GACGTCGCGATGGAGGGACTGCGCGAGGGTCTCCGCCGTCGCCGATGCAAACCGGATCAAATCTGGCGTTACGCGCGTAA
GGCGCGGGTCTGGTCGATCATGCGTCCTTACGTCGAGGCAATGGTGTCTGATGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Z9JLS9

Antitoxin

Source ID Structure

References