Detailed information of TA system TA225998

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 305..837
• Replicon: chromosome
• Accession: NZ_CP087686
• Organism: Xylella taiwanensis strain PLS19A

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: Z9JHK5
• Locus tag: LPH61_RS00005
• Protein ID: WP_038272512.1
• Coordinates: 305..577 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Z9JHR3
• Locus tag: LPH61_RS00010
• Protein ID: WP_038272513.1
• Coordinates: 577..837 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH61_RS00005 (LPH61_00005)	305..577	-	273	WP_038272512.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LPH61_RS00010 (LPH61_00010)	577..837	-	261	WP_038272513.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LPH61_RS00015 (LPH61_00015)	926..2053	-	1128	WP_114867127.1	zonular occludens toxin domain-containing protein	-
LPH61_RS00020 (LPH61_00020)	2066..2410	-	345	WP_038273069.1	DUF2523 family protein	-
LPH61_RS00025 (LPH61_00025)	2413..3798	-	1386	WP_230428213.1	furin-like repeat-containing protein	-
LPH61_RS00030 (LPH61_00030)	3978..4214	-	237	WP_230428212.1	major capsid protein	-
LPH61_RS00035 (LPH61_00035)	4223..4429	-	207	WP_038273075.1	hypothetical protein	-
LPH61_RS00040 (LPH61_00040)	4432..4746	-	315	WP_230428211.1	hypothetical protein	-
LPH61_RS00045 (LPH61_00045)	5022..5609	-	588	WP_038273076.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10638.26 Da
• Isoelectric Point: 9.9110

>T225998 WP_038272512.1 NZ_CP087686:c577-305 [Xylella taiwanensis]
MRRPAYSSQFKRDVRVSQKRGKDIEKLKILITLLIEGSPLPAMYLDHPLKGQWRSFRDAHVEPDWLLIYKVDGDVVRFER
TGRHADLFDD

Nucleotide

• Length: 273 bp

>T225998 NZ_CP121652:c3955468-3955064 [Rhizobium sp. CB3171]
GTGAAGTATTTGCTCGATAGCAATGCTGTCATCGCTCTGATGAAAGGGCATACCGGCTTCGTGAGCGAGCTTCGCAGACA
CAAGCCGCAGGATTTCGCCATCTCGGCCATCGTCGCGCACGAATTGTTTTATGGTGCCTATAAGGGGCAGCGTGTTGCAG
ACAATCTTGTGCGTGTCGATGCTTTGCAATTCGAGACACTGGATTTCGATAGGGAAGATGCCCGCGTGGTGGGCGAAATT
CGTGCCAACTTGGCTTCGCTCGGCACGCCAATCGGTGCCTATGACGTTTTGATCGCGGGTCAGGCAGTCGCCCGCGATCT
GATCCTGATAACGCGCAACGTCAGGGAATTTGAGCGCGTTCACAAGCTACGTTTCGAAGACTGGGAGTCCTTGCCGAGTA
GCTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9440.91 Da
• Isoelectric Point: 4.8047

>AT225998 WP_038272513.1 NZ_CP087686:c837-577 [Xylella taiwanensis]
MAANALVRARVDEALKDEAASVLATMGLTVSDLIRITLTKVAREKMLPFEMHSPNRLTVETFVKSECGEDVHYAESADAM
FKDLGI

Nucleotide

• Length: 261 bp

>AT225998 NZ_CP121652:c3955707-3955465 [Rhizobium sp. CB3171]
ATGGACACCGCAAAAATCTTCTGGTCCGGCCGCTCGCAGGCCATACGCCTGCCAAAGGAATTTCGTCTCGACGGCGAAGA
AGTGCGCATCCGGCGGCAGGGAAAGGCAATCATTCTGGAGCCGATCGCCGAAGATTGGGATTGGCTGGAATCCGTTACAG
GGCCGGTCGACCACGATTTTGAAGAGGCGGCGACCGAACAGCCTGCCGAGCAGCAGCGCCCCGAACTGGATATCTTCAAG
TGA

Structures

Toxin

• AlphaFold DB: Z9JHK5

Antitoxin

• AlphaFold DB: Z9JHR3