Detailed information of TA system TA225992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 344..876
• Replicon: chromosome
• Accession: NZ_CP087685
• Organism: Xylella taiwanensis strain PLS4A

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: Z9JHK5
• Locus tag: LPH40_RS00005
• Protein ID: WP_038272512.1
• Coordinates: 344..616 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Z9JHR3
• Locus tag: LPH40_RS00010
• Protein ID: WP_038272513.1
• Coordinates: 616..876 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH40_RS00005 (LPH40_00005)	344..616	-	273	WP_038272512.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LPH40_RS00010 (LPH40_00010)	616..876	-	261	WP_038272513.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LPH40_RS00015 (LPH40_00015)	965..2092	-	1128	WP_114867127.1	zonular occludens toxin domain-containing protein	-
LPH40_RS00020 (LPH40_00020)	2105..2449	-	345	WP_038273069.1	DUF2523 family protein	-
LPH40_RS00025 (LPH40_00025)	2452..3837	-	1386	WP_230428213.1	furin-like repeat-containing protein	-
LPH40_RS00030 (LPH40_00030)	4017..4253	-	237	WP_230428212.1	major capsid protein	-
LPH40_RS00035 (LPH40_00035)	4262..4468	-	207	WP_038273075.1	hypothetical protein	-
LPH40_RS00040 (LPH40_00040)	4471..4785	-	315	WP_230428211.1	hypothetical protein	-
LPH40_RS00045 (LPH40_00045)	5061..5648	-	588	WP_038273076.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10638.26 Da
• Isoelectric Point: 9.9110

>T225992 WP_038272512.1 NZ_CP087685:c616-344 [Xylella taiwanensis]
MRRPAYSSQFKRDVRVSQKRGKDIEKLKILITLLIEGSPLPAMYLDHPLKGQWRSFRDAHVEPDWLLIYKVDGDVVRFER
TGRHADLFDD

Nucleotide

• Length: 273 bp

>T225992 NZ_CP121652:c739601-739236 [Rhizobium sp. CB3171]
ATGATCTTGGTCGATACGTCGATTTGGATCGATCATTTTCATTCGCTGGACGCTAAACTTCAGTCTTTATTGGAGCAGAA
ACAGGTTCTCATCCATCCCGTCGTGATCGGTGAGATCAGCCTCGGAAACCTGAGGCAATATGATCTTGTTATGAGAAGTC
TGAGCCGGTTGTATCAGATTTCAAAGGCGCCAGATGATGACGTTCTTTATTTTATCCGGAGCAATAGATTACAAGGTATG
GGCATTGGCTATGTCGATGCTCACCTGGCGGCGGCGGCAATATTGACACCTGGCACCTATCTCTGGACGCGCGACAAGCG
GCTACAGCGCGTTGCCGAAAATCTCAGAATTGCCGCGTTGTTGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9440.91 Da
• Isoelectric Point: 4.8047

>AT225992 WP_038272513.1 NZ_CP087685:c876-616 [Xylella taiwanensis]
MAANALVRARVDEALKDEAASVLATMGLTVSDLIRITLTKVAREKMLPFEMHSPNRLTVETFVKSECGEDVHYAESADAM
FKDLGI

Nucleotide

• Length: 261 bp

>AT225992 NZ_CP121652:c739795-739598 [Rhizobium sp. CB3171]
ATGCGGACCACAGTAACCATTGATGACAAATTGCTCGCGGACGCGCGCGAAGTCACGGAATTGGCTGAGACCTCAGCGAT
CGTGCGCGAGGCGTTGAAAGCGCTTATCGAGCGAGAAGCTGCCAGAACGCTTATACGCCTTGGCGGCACGGAACCAGATA
TTGCGGCCCCTCCTCGTCGTCGGTTTGGTGTCGAATGA

Structures

Toxin

• AlphaFold DB: Z9JHK5

Antitoxin

• AlphaFold DB: Z9JHR3