Detailed information of TA system TA225978

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 601..1133
• Replicon: chromosome
• Accession: NZ_CP087681
• Organism: Xylella taiwanensis strain PLS1133

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: Z9JHK5
• Locus tag: LPH45_RS00015
• Protein ID: WP_038272512.1
• Coordinates: 601..873 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Z9JHR3
• Locus tag: LPH45_RS00020
• Protein ID: WP_038272513.1
• Coordinates: 873..1133 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH45_RS00010 (LPH45_00010)	221..565	+	345	WP_038272511.1	DUF3653 domain-containing protein	-
LPH45_RS00015 (LPH45_00015)	601..873	-	273	WP_038272512.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LPH45_RS00020 (LPH45_00020)	873..1133	-	261	WP_038272513.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LPH45_RS00025 (LPH45_00025)	1222..2349	-	1128	WP_114867127.1	zonular occludens toxin domain-containing protein	-
LPH45_RS00030 (LPH45_00030)	2362..2706	-	345	WP_038273069.1	DUF2523 family protein	-
LPH45_RS00035 (LPH45_00035)	2709..4094	-	1386	WP_230428213.1	furin-like repeat-containing protein	-
LPH45_RS00040 (LPH45_00040)	4274..4510	-	237	WP_230428212.1	major capsid protein	-
LPH45_RS00045 (LPH45_00045)	4519..4725	-	207	WP_038273075.1	hypothetical protein	-
LPH45_RS00050 (LPH45_00050)	4728..5042	-	315	WP_230428211.1	hypothetical protein	-
LPH45_RS00055 (LPH45_00055)	5318..5905	-	588	WP_038273076.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	221..16474	16253

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10638.26 Da
• Isoelectric Point: 9.9110

>T225978 WP_038272512.1 NZ_CP087681:c873-601 [Xylella taiwanensis]
MRRPAYSSQFKRDVRVSQKRGKDIEKLKILITLLIEGSPLPAMYLDHPLKGQWRSFRDAHVEPDWLLIYKVDGDVVRFER
TGRHADLFDD

Nucleotide

• Length: 273 bp

>T225978 NZ_CP121642:c2359955-2359524 [Rhizobium sp. CC1099]
ATGATCTTGCTGGATACCAATGTGATATCGGAGCCGTGGAAACCGGTTCCTGACGGGGCAGTGATCGAGTGGATGGACGC
CCAAGCCATCGAGACACTGTTCCTTTCCGCGATAACAATTGCTGAACTTCGTTTCGGGATCGCTGCCATGCCCTCAGGCA
AACGGCAAATTATCCTTCGCGATCGCCTGGAGGGCGAAGTGCTTCCGCACTTTGCCGAGCGCATCCTGCCTTTCGGCCTT
GCCACCTCGCAGTTCTACTCGGAGCTGATGGTACGAGCTCGAGTATCCGGGAAAGCGATCGGCAAGGCGGATGGATATAT
TGCAGCCACAGCAGCAGCGAACGGCCTCGCGGTCGCAACTCGAGACACCAGCCCTTTCGAGGCCGCCGGGGTGAAAGTGA
TCAATCCTTGGTCACTACAAAAAAGATATTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9440.91 Da
• Isoelectric Point: 4.8047

>AT225978 WP_038272513.1 NZ_CP087681:c1133-873 [Xylella taiwanensis]
MAANALVRARVDEALKDEAASVLATMGLTVSDLIRITLTKVAREKMLPFEMHSPNRLTVETFVKSECGEDVHYAESADAM
FKDLGI

Nucleotide

• Length: 261 bp

>AT225978 NZ_CP121642:c2360206-2359952 [Rhizobium sp. CC1099]
ATGCCGGCGGTAACTATTCGCAATCTTTCTGATGAAACGCATCGCGCCCTACGGGTGCGAGCAGCTCACCATGGCCGAAG
CACCGAGGCCGAAATCCGTGACATTATCGAGGCCGCCGTTCGTCCATCTGAACGCGTGAAACTCGGCTCCTTACTCGCGG
CCATAGGTCGTGACGCTGAGCTTTCCAACCACGACGTTGAAGCCCTGCAGCAAAATCGCGATAAAGCGCCTGCCGAGCCG
ATGACTTTCGAATGA

Structures

Toxin

• AlphaFold DB: Z9JHK5

Antitoxin

• AlphaFold DB: Z9JHR3