Detailed information of TA system TA225977

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 2788521..2789053
• Replicon: chromosome
• Accession: NZ_CP087680
• Organism: Xylella taiwanensis strain PLS407

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: Z9JHK5
• Locus tag: LPH41_RS11780
• Protein ID: WP_038272512.1
• Coordinates: 2788781..2789053 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Z9JHR3
• Locus tag: LPH41_RS11775
• Protein ID: WP_038272513.1
• Coordinates: 2788521..2788781 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH41_RS11740 (LPH41_11740)	2783749..2784336	+	588	WP_038273076.1	hypothetical protein	-
LPH41_RS11745 (LPH41_11745)	2784612..2784926	+	315	WP_230428211.1	hypothetical protein	-
LPH41_RS11750 (LPH41_11750)	2784929..2785135	+	207	WP_038273075.1	hypothetical protein	-
LPH41_RS11755 (LPH41_11755)	2785144..2785380	+	237	WP_230428212.1	major capsid protein	-
LPH41_RS11760 (LPH41_11760)	2785560..2786945	+	1386	WP_230428213.1	furin-like repeat-containing protein	-
LPH41_RS11765 (LPH41_11765)	2786948..2787292	+	345	WP_038273069.1	DUF2523 family protein	-
LPH41_RS11770 (LPH41_11770)	2787305..2788432	+	1128	WP_114867127.1	zonular occludens toxin domain-containing protein	-
LPH41_RS11775 (LPH41_11775)	2788521..2788781	+	261	WP_038272513.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LPH41_RS11780 (LPH41_11780)	2788781..2789053	+	273	WP_038272512.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LPH41_RS11785 (LPH41_11785)	2789089..2789433	-	345	WP_038272511.1	DUF3653 domain-containing protein	-
LPH41_RS11790 (LPH41_11790)	2789599..2790243	-	645	WP_038272466.1	histidine phosphatase family protein	-
LPH41_RS11795 (LPH41_11795)	2790350..2792425	-	2076	WP_230428285.1	S46 family peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2773180..2789433	16253

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10638.26 Da
• Isoelectric Point: 9.9110

>T225977 WP_038272512.1 NZ_CP087680:2788781-2789053 [Xylella taiwanensis]
MRRPAYSSQFKRDVRVSQKRGKDIEKLKILITLLIEGSPLPAMYLDHPLKGQWRSFRDAHVEPDWLLIYKVDGDVVRFER
TGRHADLFDD

Nucleotide

• Length: 273 bp

>T225977 NZ_CP121642:c2112156-2111659 [Rhizobium sp. CC1099]
GTGACCCTCAGCGCACCGACACCACTGGCCGACCATCACGAACTGGCGGAATTCATTTCCGGCGTCGTTGAACTGGACGA
TTGGCTGCGTCGCCGCGCCCGCGCCAATCAGGCAGGCGGCGCATCGCGCACATTCGTCGTGTGCGAGGGCAACCGCGTGA
TCGCCTATTATGCGCTTGCCTCCGGCGCCGTTAAGCAGCCGGAAGCACCTGGCCGTTTCCGACGCAACATGCCCGACCCG
ATTCCGGTTGCCGTTCTCGGCCGCCTCGCCATCGACCGGACCTTTCAGGGCCCCGGTCTCGGCAGGGCATTGGTGCGCGA
TGCGGGCCTGCGTCTGCTCAATGCCGCTGAAATCCTCGGTATCCGCGGCGTGCTGGTACATGCGATTTCCGATGATGCGC
GAGCCTTCTACGAGGCAGTCGGTTTTCTGCCTTCGCCGTCCGACCCCATGATGCTGATGGTTGGGCTGCGTGATTTGAAC
AACGCGCTCAATCCTTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9440.91 Da
• Isoelectric Point: 4.8047

>AT225977 WP_038272513.1 NZ_CP087680:2788521-2788781 [Xylella taiwanensis]
MAANALVRARVDEALKDEAASVLATMGLTVSDLIRITLTKVAREKMLPFEMHSPNRLTVETFVKSECGEDVHYAESADAM
FKDLGI

Nucleotide

• Length: 261 bp

>AT225977 NZ_CP121642:c2112449-2112153 [Rhizobium sp. CC1099]
ATGCCCACATCCCACACCAGTAAAAGCGCAGATGCCAGCGTGCCGCTGAATATCCGCATCAAGCCGGCGACCCGAAACCT
TATCGATCGCGCCGCCGAGCTGCTTGGCAAGACGCGCACGGATTTCATGCTGGAGGCTTCCGAGCGCCGCGCCGAGGAAG
TTCTGCTCGACCGTACGATATTCACGGTTAGTCCCGAACTCTATGCCGAGTACCTTGCCCGGCTCGATGCGCCCGCGCAA
CCCAATGAGCGACTGAAACGTACTATGACGACCAAGGCGCCGTGGGATGAGGCGTGA

Structures

Toxin

• AlphaFold DB: Z9JHK5

Antitoxin

• AlphaFold DB: Z9JHR3