Detailed information of TA system TA225965

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 137..669
• Replicon: chromosome
• Accession: NZ_CP087678
• Organism: Xylella taiwanensis strain PLS206

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: Z9JHK5
• Locus tag: LPH42_RS00005
• Protein ID: WP_038272512.1
• Coordinates: 137..409 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Z9JHR3
• Locus tag: LPH42_RS00010
• Protein ID: WP_038272513.1
• Coordinates: 409..669 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH42_RS00005 (LPH42_00005)	137..409	-	273	WP_038272512.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LPH42_RS00010 (LPH42_00010)	409..669	-	261	WP_038272513.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LPH42_RS00015 (LPH42_00015)	758..1885	-	1128	WP_114867127.1	zonular occludens toxin domain-containing protein	-
LPH42_RS00020 (LPH42_00020)	1898..2242	-	345	WP_038273069.1	DUF2523 family protein	-
LPH42_RS00025 (LPH42_00025)	2245..3630	-	1386	WP_230428213.1	furin-like repeat-containing protein	-
LPH42_RS00030 (LPH42_00030)	3810..4046	-	237	WP_230428212.1	major capsid protein	-
LPH42_RS00035 (LPH42_00035)	4055..4261	-	207	WP_038273075.1	hypothetical protein	-
LPH42_RS00040 (LPH42_00040)	4264..4578	-	315	WP_230428211.1	hypothetical protein	-
LPH42_RS00045 (LPH42_00045)	4854..5441	-	588	WP_038273076.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10638.26 Da
• Isoelectric Point: 9.9110

>T225965 WP_038272512.1 NZ_CP087678:c409-137 [Xylella taiwanensis]
MRRPAYSSQFKRDVRVSQKRGKDIEKLKILITLLIEGSPLPAMYLDHPLKGQWRSFRDAHVEPDWLLIYKVDGDVVRFER
TGRHADLFDD

Nucleotide

• Length: 273 bp

>T225965 NZ_CP121634:c4118737-4118549 [Bradyrhizobium sp. CIAT3101]
ATGAAATCGGCTGACCTTATCAAAGCTCTGAACGCCGACGGATGGGAACAGGTTGCCCAGAAAGGCAGCCACATTCAATT
CAAACACCCGACCAAGAAGGGCCGCGTCACGGTCCCTCATCCGAAGCGGGACATTCCGATTGGGACGCTGAAGAACATCG
AGAAGCAAGCCAACCTGAAACTGAAATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9440.91 Da
• Isoelectric Point: 4.8047

>AT225965 WP_038272513.1 NZ_CP087678:c669-409 [Xylella taiwanensis]
MAANALVRARVDEALKDEAASVLATMGLTVSDLIRITLTKVAREKMLPFEMHSPNRLTVETFVKSECGEDVHYAESADAM
FKDLGI

Nucleotide

• Length: 261 bp

>AT225965 NZ_CP121634:c4118502-4118110 [Bradyrhizobium sp. CIAT3101]
ATGCGATACTATATTGCACTGATCCATAAAGACGCGGACAGCGACTATGGTGTTTCGTTTCCTGATCTTCCCGGCGTGAT
CACCGCCGGCACGGATCTGGACGATGCGCGCGCTATGGCCGCAGAAGCCCTGGCCCTTCATCTGGAAGGTATGGCAGCAG
ACGGCGAAGCTGTACCTGAGCCCTCCTCTCTCGAGGAGATAATGGCGAACACTGAGAACAGAGACGGCGTTGCAGTGCTC
ATTCCCGCGCCTGCAGAAGATGTGAAGAGCGTGCGAGTAAACATCACTCTTCCGGCCGACGTTCTGAGCGAGATCGATCA
CTATGCCGAACAGCACGGCTTCACTCGATCCGGCTTTCTTGCACAAGCCGCCAAGAAAGCGATTGCGGCCTGA

Structures

Toxin

• AlphaFold DB: Z9JHK5

Antitoxin

• AlphaFold DB: Z9JHR3