Detailed information of TA system TA225963

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-VapI
• Location: 2305685..2306266
• Replicon: chromosome
• Accession: NZ_CP087677
• Organism: Xylella taiwanensis strain PLS15A

Toxin (Protein)

• Gene name: graT
• Uniprot ID: Z9JLS9
• Locus tag: LPH39_RS09520
• Protein ID: WP_038270683.1
• Coordinates: 2305685..2305963 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LPH39_RS09525
• Protein ID: WP_081755408.1
• Coordinates: 2305967..2306266 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH39_RS09485 (LPH39_09485)	2300966..2302012	+	1047	WP_038270717.1	sulfate/molybdate ABC transporter ATP-binding protein	-
LPH39_RS09490 (LPH39_09490)	2302699..2303295	-	597	WP_162814073.1	contractile injection system protein, VgrG/Pvc8 family	-
LPH39_RS09495 (LPH39_09495)	2303507..2303563	-	57	Protein_1870	phage tail protein	-
LPH39_RS09500 (LPH39_09500)	2303560..2303814	-	255	WP_230428278.1	phage tail protein	-
LPH39_RS09505 (LPH39_09505)	2303887..2304369	-	483	Protein_1872	phage tail protein I	-
LPH39_RS09510 (LPH39_09510)	2304362..2305255	-	894	WP_038270682.1	baseplate J/gp47 family protein	-
LPH39_RS09515 (LPH39_09515)	2305255..2305584	-	330	WP_230428175.1	GPW/gp25 family protein	-
LPH39_RS09520 (LPH39_09520)	2305685..2305963	+	279	WP_038270683.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LPH39_RS09525 (LPH39_09525)	2305967..2306266	+	300	WP_081755408.1	HigA family addiction module antitoxin	Antitoxin
LPH39_RS09530 (LPH39_09530)	2306276..2306572	-	297	WP_230428176.1	phage baseplate assembly protein V	-
LPH39_RS09535 (LPH39_09535)	2306526..2306735	-	210	WP_230428177.1	phage baseplate assembly protein V	-
LPH39_RS09540 (LPH39_09540)	2306735..2307388	-	654	WP_230428178.1	hypothetical protein	-
LPH39_RS09545 (LPH39_09545)	2307364..2307813	-	450	WP_230428179.1	hypothetical protein	-
LPH39_RS09550 (LPH39_09550)	2307903..2308196	-	294	WP_038270685.1	hypothetical protein	-
LPH39_RS09555 (LPH39_09555)	2308534..2308782	-	249	WP_038270686.1	hypothetical protein	-
LPH39_RS09560 (LPH39_09560)	2308821..2310205	-	1385	Protein_1883	phage major capsid protein	-
LPH39_RS09565 (LPH39_09565)	2310304..2310753	-	450	WP_230428180.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2300918..2326050	25132

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-68)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10669.11 Da
• Isoelectric Point: 9.0910

>T225963 WP_038270683.1 NZ_CP087677:2305685-2305963 [Xylella taiwanensis]
MIKTFADQDTESLFNGSRVRRFIHIEAVARRKLIQLHAAATLSFLNAPPGNRLETLKGDRQGQHSIRINNQFRLCFIWEN
GDAYQVEIVDYH

Nucleotide

• Length: 279 bp

>T225963 NZ_CP121632:3944199-3944381 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10980.69 Da
• Isoelectric Point: 9.0879

>AT225963 WP_081755408.1 NZ_CP087677:2305967-2306266 [Xylella taiwanensis]
MSMSKTLPPIHPGEILREEFMAPLGLSSNALAKAIGVTAARINEIVRERRGITADTALRLARYFGTDPQSWLNLEQHYAL
ECAKRDLGEALSRIHPRVA

Nucleotide

• Length: 300 bp

>AT225963 NZ_CP121632:3944474-3944878 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: Z9JLS9