Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-VapI |
| Location | 2313152..2313733 | Replicon | chromosome |
| Accession | NZ_CP087676 | ||
| Organism | Xylella taiwanensis strain PLS396 | ||
Toxin (Protein)
| Gene name | graT | Uniprot ID | Z9JLS9 |
| Locus tag | LPH43_RS09580 | Protein ID | WP_038270683.1 |
| Coordinates | 2313152..2313430 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LPH43_RS09585 | Protein ID | WP_081755408.1 |
| Coordinates | 2313434..2313733 (+) | Length | 100 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LPH43_RS09545 (LPH43_09545) | 2308433..2309479 | + | 1047 | WP_038270717.1 | sulfate/molybdate ABC transporter ATP-binding protein | - |
| LPH43_RS09550 (LPH43_09550) | 2310166..2310762 | - | 597 | WP_162814073.1 | contractile injection system protein, VgrG/Pvc8 family | - |
| LPH43_RS09555 (LPH43_09555) | 2310974..2311030 | - | 57 | Protein_1886 | phage tail protein | - |
| LPH43_RS09560 (LPH43_09560) | 2311027..2311281 | - | 255 | WP_230428278.1 | phage tail protein | - |
| LPH43_RS09565 (LPH43_09565) | 2311354..2311836 | - | 483 | Protein_1888 | phage tail protein I | - |
| LPH43_RS09570 (LPH43_09570) | 2311829..2312722 | - | 894 | WP_038270682.1 | baseplate J/gp47 family protein | - |
| LPH43_RS09575 (LPH43_09575) | 2312722..2313051 | - | 330 | WP_230428175.1 | GPW/gp25 family protein | - |
| LPH43_RS09580 (LPH43_09580) | 2313152..2313430 | + | 279 | WP_038270683.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LPH43_RS09585 (LPH43_09585) | 2313434..2313733 | + | 300 | WP_081755408.1 | HigA family addiction module antitoxin | Antitoxin |
| LPH43_RS09590 (LPH43_09590) | 2313743..2314039 | - | 297 | WP_230428176.1 | phage baseplate assembly protein V | - |
| LPH43_RS09595 (LPH43_09595) | 2313993..2314202 | - | 210 | WP_230428177.1 | phage baseplate assembly protein V | - |
| LPH43_RS09600 (LPH43_09600) | 2314202..2314855 | - | 654 | WP_230428178.1 | hypothetical protein | - |
| LPH43_RS09605 (LPH43_09605) | 2314831..2315247 | - | 417 | WP_230428499.1 | hypothetical protein | - |
| LPH43_RS09610 (LPH43_09610) | 2315370..2315663 | - | 294 | WP_038270685.1 | hypothetical protein | - |
| LPH43_RS09615 (LPH43_09615) | 2315644..2315874 | - | 231 | WP_230428500.1 | hypothetical protein | - |
| LPH43_RS09620 (LPH43_09620) | 2316001..2316249 | - | 249 | WP_038270686.1 | hypothetical protein | - |
| LPH43_RS09625 (LPH43_09625) | 2316288..2317672 | - | 1385 | Protein_1900 | phage major capsid protein | - |
| LPH43_RS09630 (LPH43_09630) | 2317771..2318220 | - | 450 | WP_230428180.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2308385..2349106 | 40721 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10669.11 Da Isoelectric Point: 9.0910
>T225958 WP_038270683.1 NZ_CP087676:2313152-2313430 [Xylella taiwanensis]
MIKTFADQDTESLFNGSRVRRFIHIEAVARRKLIQLHAAATLSFLNAPPGNRLETLKGDRQGQHSIRINNQFRLCFIWEN
GDAYQVEIVDYH
MIKTFADQDTESLFNGSRVRRFIHIEAVARRKLIQLHAAATLSFLNAPPGNRLETLKGDRQGQHSIRINNQFRLCFIWEN
GDAYQVEIVDYH
Download Length: 279 bp
>T225958 NZ_CP121628:12135-12422 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG
Antitoxin
Download Length: 100 a.a. Molecular weight: 10980.69 Da Isoelectric Point: 9.0879
>AT225958 WP_081755408.1 NZ_CP087676:2313434-2313733 [Xylella taiwanensis]
MSMSKTLPPIHPGEILREEFMAPLGLSSNALAKAIGVTAARINEIVRERRGITADTALRLARYFGTDPQSWLNLEQHYAL
ECAKRDLGEALSRIHPRVA
MSMSKTLPPIHPGEILREEFMAPLGLSSNALAKAIGVTAARINEIVRERRGITADTALRLARYFGTDPQSWLNLEQHYAL
ECAKRDLGEALSRIHPRVA
Download Length: 300 bp
>AT225958 NZ_CP121628:12409-12723 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|