Detailed information of TA system TA022592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 475475..476074
• Replicon: chromosome
• Accession: NC_010161
• Organism: Bartonella tribocorum CIP 105476

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A5B9CYQ5
• Locus tag: BTR_RS02020
• Protein ID: WP_012230946.1
• Coordinates: 475475..475756 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BTR_RS02025
• Protein ID: WP_012230948.1
• Coordinates: 475775..476074 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTR_RS01990	470978..471385	+	408	WP_012230938.1	hypothetical protein	-
BTR_RS01995	471462..472850	+	1389	WP_012230940.1	hypothetical protein	-
BTR_RS02000	472847..473260	+	414	WP_012230942.1	hypothetical protein	-
BTR_RS02005	473337..474260	+	924	WP_038473276.1	hypothetical protein	-
BTR_RS02010	474322..474783	+	462	WP_081458175.1	hypothetical protein	-
BTR_RS02015	474780..475193	+	414	WP_012230944.1	hypothetical protein	-
BTR_RS02020	475475..475756	+	282	WP_012230946.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BTR_RS02025	475775..476074	+	300	WP_012230948.1	HigA family addiction module antidote protein	Antitoxin
BTR_RS02030	476132..477169	-	1038	WP_012230950.1	tyrosine-type recombinase/integrase	-
BTR_RS02035	477172..477420	-	249	WP_012230952.1	hypothetical protein	-
BTR_RS02040	477532..478155	-	624	WP_012230954.1	YqaJ viral recombinase family protein	-
BTR_RS02045	478157..478963	-	807	WP_038473282.1	ERF family protein	-
BTR_RS02050	479037..479579	-	543	WP_012230958.1	hypothetical protein	-
BTR_RS02055	479573..480064	-	492	WP_012230960.1	hypothetical protein	-
BTR_RS02060	480068..480682	-	615	WP_012230962.1	hypothetical protein	-
BTR_RS02065	480694..481011	-	318	WP_012230964.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (5-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (2-89)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10675.46 Da
• Isoelectric Point: 10.2972

>T22592 WP_012230946.1 NC_010161:475475-475756 [Bartonella tribocorum CIP 105476]
MAIVSFKHKGLKLFYTTGSTKAIRPDHVKKLRVILTALTSATTPDMLRAPAFKMHPLKGELTGYYSIWVNGNWRVTFRFI
GTDVELVDYQDYH

Nucleotide

• Length: 282 bp

>T22592 NC_010161:475475-475756 [Bartonella tribocorum CIP 105476]
ATGGCAATTGTGAGTTTCAAACATAAGGGCTTAAAATTATTTTACACAACAGGTTCCACAAAAGCTATTCGACCAGATCA
CGTAAAGAAATTACGCGTTATCTTAACGGCTTTAACAAGTGCTACGACACCTGATATGTTGAGAGCGCCTGCCTTTAAAA
TGCATCCTCTTAAAGGCGAACTTACAGGATATTATTCTATATGGGTGAATGGAAATTGGCGTGTTACTTTTCGCTTTATA
GGAACAGATGTGGAGCTTGTTGATTATCAAGATTACCACTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11112.87 Da
• Isoelectric Point: 6.9876

>AT22592 WP_012230948.1 NC_010161:475775-476074 [Bartonella tribocorum CIP 105476]
MMHNPAHPGEVLKVAFLEEMGITIQKLADHLHMTRASLSRVINGHASISTELAIKLELAGFSKAKFWLDMQTNYNLWQTM
QQTQPPISPLVSDVSQTQL

Nucleotide

• Length: 300 bp

>AT22592 NC_010161:475775-476074 [Bartonella tribocorum CIP 105476]
ATGATGCATAACCCCGCACATCCGGGCGAAGTTCTAAAAGTAGCTTTCTTAGAAGAAATGGGGATAACAATACAGAAATT
AGCTGATCATCTCCATATGACAAGAGCTTCTCTATCAAGAGTGATTAACGGTCATGCTTCTATAAGTACCGAACTTGCAA
TTAAATTAGAATTAGCTGGTTTTAGTAAAGCAAAATTTTGGCTGGATATGCAAACAAACTATAATTTATGGCAAACAATG
CAACAGACACAACCACCTATTTCTCCTCTGGTTTCTGATGTATCTCAAACGCAGCTTTGA

Structures

Toxin

• AlphaFold DB: A0A5B9CYQ5