Detailed information of TA system TA022591

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 433195..433726
• Replicon: chromosome
• Accession: NC_010161
• Organism: Bartonella tribocorum CIP 105476

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: -
• Locus tag: BTR_RS01865
• Protein ID: WP_038473264.1
• Coordinates: 433195..433467 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A9INW3
• Locus tag: BTR_RS01870
• Protein ID: WP_012230893.1
• Coordinates: 433469..433726 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTR_RS01855	429027..429581	+	555	WP_012230889.1	biotin transporter BioY	-
BTR_RS01860	430003..430311	+	309	WP_038473261.1	hypothetical protein	-
BTR_RS12125	431077..431621	-	545	Protein_336	hypothetical protein	-
BTR_RS01865	433195..433467	-	273	WP_038473264.1	type II toxin-antitoxin system YafQ family toxin	Toxin
BTR_RS01870	433469..433726	-	258	WP_012230893.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BTR_RS01875	434014..434627	-	614	Protein_339	hypothetical protein	-
BTR_RS01885	435074..436837	+	1764	WP_012230898.1	ShlB/FhaC/HecB family hemolysin secretion/activation protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (7-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10767.62 Da
• Isoelectric Point: 10.2928

>T22591 WP_038473264.1 NC_010161:c433467-433195 [Bartonella tribocorum CIP 105476]
MLIPVRSRQFKRDVRKAEKRGKNMNKLRTLLSLLIEEKPLPRHYCDHPLKGDWVGYHDIHIEPDWLLIYRIEGGKLHLIR
TGTHSDLFKE

Nucleotide

• Length: 273 bp

>T22591 NC_010161:c433467-433195 [Bartonella tribocorum CIP 105476]
ATGCTGATACCCGTCCGCTCAAGACAATTTAAACGTGACGTGCGCAAAGCGGAAAAACGCGGTAAAAATATGAATAAGCT
GCGTACACTATTGAGTCTTCTAATTGAAGAAAAGCCATTACCAAGACATTACTGTGATCATCCACTAAAAGGCGATTGGG
TAGGATATCATGATATTCATATCGAACCAGATTGGCTGCTTATTTATAGAATAGAAGGAGGTAAATTACATCTTATTCGT
ACAGGAACCCACTCTGATCTTTTCAAAGAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9467.19 Da
• Isoelectric Point: 10.1958

>AT22591 WP_012230893.1 NC_010161:c433726-433469 [Bartonella tribocorum CIP 105476]
MKTDSVVRARIPAEMKKQAMITLERMGLSASDLIRITFLRVAEEGCLPFDLKVPNSVTRKAIKELDEGKGKTFKNADALF
KDLGI

Nucleotide

• Length: 258 bp

>AT22591 NC_010161:c433726-433469 [Bartonella tribocorum CIP 105476]
ATGAAAACCGATTCTGTTGTTCGCGCTCGCATTCCTGCTGAAATGAAAAAACAAGCGATGATTACTTTAGAACGTATGGG
ATTAAGTGCATCAGACCTTATCCGCATAACATTTTTGCGTGTCGCTGAAGAAGGTTGTTTGCCTTTTGATCTTAAAGTAC
CTAATAGTGTCACACGTAAAGCTATAAAGGAATTAGATGAAGGTAAAGGTAAGACATTTAAAAACGCTGATGCCCTTTTT
AAGGATTTAGGCATTTAA

Structures

Antitoxin

• AlphaFold DB: A9INW3