Detailed information of TA system TA022590

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 397025..397652
• Replicon: chromosome
• Accession: NC_010161
• Organism: Bartonella tribocorum CIP 105476

Toxin (Protein)

• Gene name: graT
• Uniprot ID: A9INI4
• Locus tag: BTR_RS01610
• Protein ID: WP_012230802.1
• Coordinates: 397025..397339 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: BTR_RS01615
• Protein ID: WP_012230805.1
• Coordinates: 397356..397652 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTR_RS01585	393515..394621	-	1107	WP_012230791.1	hypothetical protein	-
BTR_RS01590	394621..395448	-	828	WP_012230798.1	baseplate J/gp47 family protein	-
BTR_RS01595	395445..395786	-	342	WP_038473244.1	GPW/gp25 family protein	-
BTR_RS01600	395783..396448	-	666	WP_012230800.1	phage baseplate assembly protein V	-
BTR_RS01605	396429..396971	-	543	WP_012230801.1	hypothetical protein	-
BTR_RS01610	397025..397339	+	315	WP_012230802.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BTR_RS01615	397356..397652	+	297	WP_012230805.1	HigA family addiction module antidote protein	Antitoxin
BTR_RS01620	397699..397977	-	279	WP_012230806.1	hypothetical protein	-
BTR_RS01625	397974..398296	-	323	Protein_291	phage antirepressor KilAC domain-containing protein	-
BTR_RS01630	398383..398708	-	326	Protein_292	Rha family transcriptional regulator	-
BTR_RS01635	399089..400174	+	1086	WP_012230810.1	hypothetical protein	-
BTR_RS01640	400178..400555	-	378	Protein_294	hypothetical protein	-
BTR_RS01645	400557..401633	-	1077	WP_012230813.1	major capsid protein	-
BTR_RS01650	401646..402014	-	369	WP_012230814.1	head decoration protein	-
BTR_RS01655	402011..402355	-	345	WP_038474435.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	372788..425174	52386

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (12-104)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (5-94)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12140.05 Da
• Isoelectric Point: 10.0702

>T22590 WP_012230802.1 NC_010161:397025-397339 [Bartonella tribocorum CIP 105476]
MIHKRTHRGDLVIESFADKRCKDLLEGKTPKGFPATLVRIAQRKLFMLDKAVDLKDLRSPPGNHLEALKGERKGQYSIRI
NNQFRLCFEWRTNGAYEVEIVDYH

Nucleotide

• Length: 315 bp

>T22590 NC_010161:397025-397339 [Bartonella tribocorum CIP 105476]
ATGATACATAAAAGAACGCATAGAGGTGATTTGGTGATTGAATCTTTTGCGGATAAGCGGTGTAAAGATCTTTTAGAAGG
CAAGACACCCAAAGGTTTTCCTGCGACATTGGTACGCATAGCACAAAGAAAATTGTTTATGCTCGATAAAGCAGTTGATC
TTAAAGATTTGCGCAGTCCTCCAGGAAATCATTTAGAAGCATTGAAAGGAGAGCGTAAAGGTCAATATTCTATTCGTATT
AATAACCAGTTTCGTCTTTGTTTTGAATGGCGTACTAATGGTGCCTATGAAGTTGAAATTGTAGATTATCATTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11294.96 Da
• Isoelectric Point: 5.7188

>AT22590 WP_012230805.1 NC_010161:397356-397652 [Bartonella tribocorum CIP 105476]
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIIAENSPITPDTALRLASFFDTTAEFWLNMQAAYDVHIL
QAEKADEFAKINKFECRT

Nucleotide

• Length: 297 bp

>AT22590 NC_010161:397356-397652 [Bartonella tribocorum CIP 105476]
ATGAAAAATTATATTGCAATACATCCTGGAGAAATTTTACGGGAGGAATATTTAAAAGAATATGCTCTTTCTGCTTATGC
TCTTGCAAAAGCATTGAATGTTCCACGCACGAGGATAGAACGTATTATTGCGGAAAATAGCCCAATAACTCCTGATACCG
CTCTCAGACTGGCTTCTTTTTTTGATACGACAGCTGAGTTCTGGCTTAATATGCAAGCTGCTTATGATGTTCATATTTTA
CAAGCCGAAAAAGCAGATGAATTTGCCAAAATTAATAAATTTGAATGTAGAACTTAA

Structures

Toxin

• AlphaFold DB: A9INI4