Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4093211..4093905 Replicon chromosome
Accession NC_010159
Organism Yersinia pestis Angola

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag YPANGOLA_RS20205 Protein ID WP_002214787.1
Coordinates 4093211..4093507 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag YPANGOLA_RS20210 Protein ID WP_002209924.1
Coordinates 4093507..4093905 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPANGOLA_RS20170 4088333..4089850 + 1518 WP_002209930.1 lysine--tRNA ligase -
YPANGOLA_RS20180 4090283..4091497 + 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
YPANGOLA_RS20185 4091579..4091764 - 186 WP_002209928.1 hypothetical protein -
YPANGOLA_RS20195 4092362..4092622 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
YPANGOLA_RS20200 4092685..4093047 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
YPANGOLA_RS20205 4093211..4093507 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
YPANGOLA_RS20210 4093507..4093905 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
YPANGOLA_RS20215 4094305..4096596 - 2292 WP_002209923.1 toprim domain-containing protein -
YPANGOLA_RS20220 4096896..4097222 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
YPANGOLA_RS25450 4097215..4097367 + 153 WP_002209921.1 hypothetical protein -
YPANGOLA_RS20230 4097381..4097581 - 201 WP_002209920.1 AlpA family transcriptional regulator -
YPANGOLA_RS20235 4097763..4098095 - 333 WP_002214791.1 hypothetical protein -
YPANGOLA_RS20240 4098101..4098337 - 237 WP_002214792.1 hypothetical protein -
YPANGOLA_RS20245 4098350..4098715 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T22589 WP_002214787.1 NC_010159:4093211-4093507 [Yersinia pestis Angola]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T22589 NC_010159:4093211-4093507 [Yersinia pestis Angola]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT22589 WP_002209924.1 NC_010159:4093507-4093905 [Yersinia pestis Angola]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT22589 NC_010159:4093507-4093905 [Yersinia pestis Angola]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References