Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
| Location | 330300..330886 | Replicon | chromosome |
| Accession | NZ_CP087634 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain DD02297 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | W8VD46 |
| Locus tag | LMH52_RS01535 | Protein ID | WP_002920800.1 |
| Coordinates | 330518..330886 (+) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A0H3GZM4 |
| Locus tag | LMH52_RS01530 | Protein ID | WP_002920802.1 |
| Coordinates | 330300..330521 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMH52_RS01510 (LMH52_01510) | 326457..327383 | + | 927 | WP_002920807.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
| LMH52_RS01515 (LMH52_01515) | 327380..328657 | + | 1278 | WP_002920806.1 | branched chain amino acid ABC transporter permease LivM | - |
| LMH52_RS01520 (LMH52_01520) | 328654..329421 | + | 768 | WP_002920803.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
| LMH52_RS01525 (LMH52_01525) | 329423..330136 | + | 714 | WP_004145133.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF | - |
| LMH52_RS01530 (LMH52_01530) | 330300..330521 | + | 222 | WP_002920802.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LMH52_RS01535 (LMH52_01535) | 330518..330886 | + | 369 | WP_002920800.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| LMH52_RS01540 (LMH52_01540) | 331159..332475 | + | 1317 | WP_002920796.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
| LMH52_RS01545 (LMH52_01545) | 332582..333469 | + | 888 | WP_002920792.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
| LMH52_RS01550 (LMH52_01550) | 333466..334311 | + | 846 | WP_002920789.1 | sn-glycerol-3-phosphate ABC transporter permease UgpE | - |
| LMH52_RS01555 (LMH52_01555) | 334313..335383 | + | 1071 | WP_002920787.1 | sn-glycerol-3-phosphate import ATP-binding protein UgpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | - | 327380..336120 | 8740 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13552.92 Da Isoelectric Point: 8.6410
>T225758 WP_002920800.1 NZ_CP087634:330518-330886 [Klebsiella pneumoniae subsp. pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG
Download Length: 369 bp
>T225758 NZ_CP121310:350198-350617 [Ensifer adhaerens]
ATGATCGTCCTGGACACGAATGTCGTCTCGGAGGCGATGAAGCCGGCCCCGGATTTGGCCGTGCGCAATTGGTTGAATGA
CCAGGTAGCCGAAACCTTGTTTTTGTCCAGTGTAACGCTGGCGGAACTGCTGTTTGGCATCGCCGCGCTACCGGAGGGCC
GGCGCAAAAAGGCGTTGGCCGACACGCTTGATGGCCTGCTCGAACTGTTCGACGATCGCGTGTTGTCATTCGACACTGCG
GCGGCTCGGCACTATGCGGACCTTACGGCAACCCCGCGAGCAGTGGGGAAGGGATTCCAGACGCCTGATGGATACATTGC
GGCTATTGCAGCCTCCAAGGGATTTACAATCGCGACCCGCGATACAAGTCCCTTTGAGGCGGCAGGAGTCCCCGTCGTCA
ATCCTTGGAACCACCTATAG
ATGATCGTCCTGGACACGAATGTCGTCTCGGAGGCGATGAAGCCGGCCCCGGATTTGGCCGTGCGCAATTGGTTGAATGA
CCAGGTAGCCGAAACCTTGTTTTTGTCCAGTGTAACGCTGGCGGAACTGCTGTTTGGCATCGCCGCGCTACCGGAGGGCC
GGCGCAAAAAGGCGTTGGCCGACACGCTTGATGGCCTGCTCGAACTGTTCGACGATCGCGTGTTGTCATTCGACACTGCG
GCGGCTCGGCACTATGCGGACCTTACGGCAACCCCGCGAGCAGTGGGGAAGGGATTCCAGACGCCTGATGGATACATTGC
GGCTATTGCAGCCTCCAAGGGATTTACAATCGCGACCCGCGATACAAGTCCCTTTGAGGCGGCAGGAGTCCCCGTCGTCA
ATCCTTGGAACCACCTATAG
Antitoxin
Download Length: 74 a.a. Molecular weight: 8181.18 Da Isoelectric Point: 4.7769
>AT225758 WP_002920802.1 NZ_CP087634:330300-330521 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK
Download Length: 222 bp
>AT225758 NZ_CP121310:349947-350201 [Ensifer adhaerens]
ATGGCTATCCTGACAGTACGAAATGTACCTGATGAAGTGCACCGGGCTTTGCGCGTCCGGGCGGCAAATCACGGCCGCAG
CACAGAGGCGGAAGTCCGCGAGATTCTGGAACGTGCGGTAAAGCCCGAACAGCGTATTCGCATCGGCGATGCCTTGGCTG
AGTTGAGCGGGCGGCTTGGCTTGACCAATGATGATTTTGAAGTGTTCGACCAGATGCAAGACAAAGCGCCGGCGGAGCCG
ATGAGGTTTGAATGA
ATGGCTATCCTGACAGTACGAAATGTACCTGATGAAGTGCACCGGGCTTTGCGCGTCCGGGCGGCAAATCACGGCCGCAG
CACAGAGGCGGAAGTCCGCGAGATTCTGGAACGTGCGGTAAAGCCCGAACAGCGTATTCGCATCGGCGATGCCTTGGCTG
AGTTGAGCGGGCGGCTTGGCTTGACCAATGATGATTTTGAAGTGTTCGACCAGATGCAAGACAAAGCGCCGGCGGAGCCG
ATGAGGTTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GUD1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GZM4 |