Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 62200..62927 | Replicon | plasmid pDD02341-2 |
| Accession | NZ_CP087631 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain DD02341 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | LMH53_RS28130 | Protein ID | WP_011251285.1 |
| Coordinates | 62616..62927 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LMH53_RS28125 | Protein ID | WP_011251286.1 |
| Coordinates | 62200..62619 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMH53_RS28100 (LMH53_28100) | 57654..58892 | + | 1239 | Protein_56 | copper/silver sensor histidine kinase SilS | - |
| LMH53_RS28105 (LMH53_28105) | 58925..59893 | + | 969 | WP_004225014.1 | IS5 family transposase | - |
| LMH53_RS28110 (LMH53_28110) | 60227..60634 | + | 408 | WP_227630754.1 | hypothetical protein | - |
| LMH53_RS28115 (LMH53_28115) | 60648..61013 | + | 366 | WP_048333448.1 | hypothetical protein | - |
| LMH53_RS28120 (LMH53_28120) | 61085..62053 | - | 969 | WP_086642568.1 | IS5 family transposase | - |
| LMH53_RS28125 (LMH53_28125) | 62200..62619 | - | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| LMH53_RS28130 (LMH53_28130) | 62616..62927 | - | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LMH53_RS28135 (LMH53_28135) | 63132..63569 | - | 438 | Protein_63 | DDE-type integrase/transposase/recombinase | - |
| LMH53_RS28140 (LMH53_28140) | 63704..64401 | + | 698 | WP_223175001.1 | IS1-like element IS1A family transposase | - |
| LMH53_RS28145 (LMH53_28145) | 64403..64852 | + | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
| LMH53_RS28150 (LMH53_28150) | 64869..65180 | + | 312 | WP_011251282.1 | hypothetical protein | - |
| LMH53_RS28155 (LMH53_28155) | 65194..65535 | + | 342 | WP_011251281.1 | hypothetical protein | - |
| LMH53_RS28160 (LMH53_28160) | 65595..66551 | + | 957 | WP_011251280.1 | DsbA family protein | - |
| LMH53_RS28165 (LMH53_28165) | 66668..67243 | + | 576 | WP_074424927.1 | hypothetical protein | - |
| LMH53_RS28170 (LMH53_28170) | 67351..67866 | + | 516 | WP_094819131.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | iucA / iucB / iucC / iucD / iutA / rmpA | 1..178159 | 178159 | |
| - | inside | IScluster/Tn | - | - | 58925..64401 | 5476 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T225751 WP_011251285.1 NZ_CP087631:c62927-62616 [Klebsiella pneumoniae subsp. pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
>T225751 NZ_CP121298:3752106-3752324 [Salmonella enterica subsp. enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT225751 WP_011251286.1 NZ_CP087631:c62619-62200 [Klebsiella pneumoniae subsp. pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
>AT225751 NZ_CP121298:3751704-3752078 [Salmonella enterica subsp. enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|