Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1525252..1525907 Replicon chromosome
Accession NC_010117
Organism Coxiella burnetii RSA 331

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag COXBURSA331_RS08255 Protein ID WP_080512993.1
Coordinates 1525569..1525907 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag COXBURSA331_RS08250 Protein ID WP_010958263.1
Coordinates 1525252..1525563 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COXBURSA331_RS08225 1520530..1521207 - 678 Protein_1549 cyclin -
COXBURSA331_RS08235 1521525..1522907 - 1383 WP_040939770.1 cysteine--tRNA ligase -
COXBURSA331_RS08240 1522898..1524295 - 1398 WP_010958261.1 glutamate--tRNA ligase -
COXBURSA331_RS08245 1524452..1525183 + 732 WP_010958262.1 UDP-2,3-diacylglucosamine diphosphatase -
COXBURSA331_RS08250 1525252..1525563 - 312 WP_010958263.1 HigA family addiction module antidote protein Antitoxin
COXBURSA331_RS08255 1525569..1525907 - 339 WP_080512993.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
COXBURSA331_RS08260 1526264..1527409 + 1146 WP_010957722.1 ISAs1 family transposase -
COXBURSA331_RS08265 1527737..1529410 + 1674 WP_012220680.1 CBU_1493 family Dot/Icm T4SS effector -
COXBURSA331_RS12025 1529576..1529815 - 240 WP_012220681.1 hypothetical protein -
COXBURSA331_RS08275 1529814..1530833 + 1020 WP_005772222.1 IS110-like element IS1111A family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(23-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(26-72)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13437.72 Da        Isoelectric Point: 10.5783

>T22567 WP_080512993.1 NC_010117:c1525907-1525569 [Coxiella burnetii RSA 331]
MPLTLYIMLDVTRKTVILEVIIKSFKDKYTKYLYKGVSVSKWRAIRKQAERRLQILDSVTSLDDLRSLPSNRFESLRGNR
KGQFSIRINKQWRICFKWINNEPTEVEIVDYH

Download         Length: 339 bp

>T22567 NC_010117:c1525907-1525569 [Coxiella burnetii RSA 331]
TTGCCTCTTACGCTGTATATTATGCTTGATGTAACGCGTAAAACTGTTATCCTTGAAGTGATAATAAAAAGTTTCAAGGA
CAAATACACTAAATATTTATATAAAGGTGTATCCGTTTCAAAATGGCGAGCCATACGAAAGCAGGCGGAAAGACGGCTTC
AGATTTTGGATTCAGTGACATCGTTAGATGATTTGAGAAGTTTGCCAAGCAATCGTTTTGAATCGTTGCGGGGGAATAGA
AAAGGACAATTTAGTATAAGGATTAATAAGCAATGGCGCATTTGTTTTAAGTGGATTAACAATGAGCCAACTGAAGTTGA
AATTGTGGATTATCATTAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11458.39 Da        Isoelectric Point: 10.1699

>AT22567 WP_010958263.1 NC_010117:c1525563-1525252 [Coxiella burnetii RSA 331]
MKMAANRMRPIHPGEILAEELGFLDKMSANQLAKHLAIPTNRVTAILNGARSITADTALRLAKFFGTTPEFWLNLQDAYD
IKMALKKSGKKIEKEVTPYDQAA

Download         Length: 312 bp

>AT22567 NC_010117:c1525563-1525252 [Coxiella burnetii RSA 331]
ATGAAAATGGCAGCTAATAGAATGCGACCCATACATCCAGGTGAGATCCTTGCTGAAGAGTTGGGGTTTTTAGATAAGAT
GTCAGCTAATCAGTTAGCTAAACATTTAGCAATTCCGACCAACCGAGTGACCGCCATTCTCAATGGCGCGCGATCCATTA
CGGCGGATACCGCGCTACGATTGGCTAAGTTTTTTGGGACGACGCCGGAATTTTGGCTAAATCTCCAAGACGCCTATGAC
ATAAAAATGGCATTGAAAAAGTCCGGCAAAAAAATCGAAAAAGAAGTAACCCCTTACGACCAAGCCGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References