Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 325564..326150 Replicon chromosome
Accession NZ_CP087611
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02172

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag LMH59_RS01515 Protein ID WP_002920800.1
Coordinates 325782..326150 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag LMH59_RS01510 Protein ID WP_004174006.1
Coordinates 325564..325785 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH59_RS01490 (321721) 321721..322647 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LMH59_RS01495 (322644) 322644..323921 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
LMH59_RS01500 (323918) 323918..324685 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LMH59_RS01505 (324687) 324687..325400 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
LMH59_RS01510 (325564) 325564..325785 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LMH59_RS01515 (325782) 325782..326150 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LMH59_RS01520 (326423) 326423..327739 + 1317 WP_247333502.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
LMH59_RS01525 (327846) 327846..328733 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
LMH59_RS01530 (328730) 328730..329575 + 846 WP_004181473.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
LMH59_RS01535 (329577) 329577..330647 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 322644..331384 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T225652 WP_002920800.1 NZ_CP087611:325782-326150 [Klebsiella pneumoniae subsp. pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T225652 NZ_CP121261:4693661-4694974 [Achromobacter spanius]
ATGAACGGCGAATTCGTCGGCACCTGGAGCGTGCAACCGCATGTCGGAGAAGTCCTGCAGTATGCCGACGCCTGGGTGGC
ATCCGGACAGGGGCGCCCGCTGTCGCTGTCCCTCCCCTTCACCCCGGGCAATCCGCCGCACCGTGGCGAAGCCGTGCGCA
CCTACTTCGAAAACCTGCTGCCGGACAGCAAGGAAATCCGCGAGCGCGTGGCACGTCGGTACCAGGCCGGCTCGACCAAT
GCGTTCGCCTTGCTGGCTGAAGTTGGTCGGGACTGTGTCGGCGCGCTGCAGGTGGTGCCGGGCCCCGATGCGCCGGACGG
CGTGCAAGAGGTGAACGCGGTTCCGATGACCGACGCCGAGATTGCCCAGCTGCTTCGCAACACCCTGGCGCCAGGCCCCC
TGGGCCGGAACGCTGCCGAGGATGAAGACTTCCGCATCTCCATTGCCGGAGCACAGGAAAAGTCGGCCATGCTCTGGTAC
GACGGGCGGTGGTGCCGGCCGCATGGCGCGACACCGACCACTCACATCTTCAAGCTGCCACTGGGCCTGGTCGCAAACAT
GAAGTTCGACATGAGCGATTCGGTCGAAAACGAGTGGCTGTGCTCCGAAATCCTGCGCGCCTACCAAATGCCTGTGGCGC
GCACCGAGCCCCTGATGTTCGAGGACATGAAGGTGCTGGCGGTCGAGCGCTTCGACCGGATGTGGTGGGAGAGCCCAGAG
GGCAAGCGCTGGCTCATCCGGCTGCCGCAGGAAGACATGTGCCAAGCGACGGCAACCCCGCCGCATTTGAAGTACGAGTC
CGACGGCGGGCCGGGTGTGCGCCAAATCATGAAGCTGTTGGCTACGTCGCGCGCGCCTGACCGCGACCGTCGCACGTTCT
TCCAGGCCCAGGTCCTCTTCTGGATGCTGCGTGCCACGGATGGCCACGCGAAGAACTTCAGCATTTTCCTGCGCCAGGGT
GGCACCTACGAACTCACCCCGCTGTACGACGTACTTTCCGCTTACCCCGTCATCGGCAAGGGTGCGAAAAAGCTGTCTCC
GTACGACGCCAAGATGGCCATGGCCGTGCGCTCGAAAAACCCCCACTGGGTCATGCGCGACATCCTGCGTCGGCACTGGA
TCGCCGTGGGCACCGAGCATGGCGTAGTGAATCCCGACGGTAAGGGGGTGGAGCATGTCCTCGACGACCTGGTGGCGCGC
ACGCCCGGGGTCGTGAAGGCCGTCCGCGCGCTACTGCCGGCGGGATTCCCCATGCACGTGGCCGACTGCATCCTCAACGG
CCTGCAAGAGGCCGCTGACCACCTGGCAGGTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT225652 WP_004174006.1 NZ_CP087611:325564-325785 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT225652 NZ_CP121261:4693357-4693617 [Achromobacter spanius]
ATGACCGATTTCACCGTCCGTACGGCGGAGCAGCTGCCTGCACTGCTCCAGGGTTTTCGCAAACAGTCCGGCCTGACCCA
AGCGGATACGGCGATGCGCCTGGGCGTCAGCCAGCAGGCCTTGTCTCATCTCGAGCGCCATGCCGACAAGGTCAGCGCCG
ACCGCCTGCTGGAGCTTCTGAGCATCCTGGGCGTCGAGCTCGTGCTGCGCAAGACCAGCGAATCGCCGTCGCCCAAGGCG
TCGGTTGGCCCCAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References