Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 168040..168293 | Replicon | plasmid pDD01304-2 |
| Accession | NZ_CP087608 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain DD01304 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | LMH54_RS29350 | Protein ID | WP_001312851.1 |
| Coordinates | 168144..168293 (+) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 168040..168099 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMH54_RS29310 (163700) | 163700..163765 | - | 66 | Protein_213 | helix-turn-helix domain-containing protein | - |
| LMH54_RS29315 (163818) | 163818..164522 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| LMH54_RS29320 (164547) | 164547..164747 | + | 201 | WP_072354025.1 | hypothetical protein | - |
| LMH54_RS29325 (164767) | 164767..165513 | + | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
| LMH54_RS29330 (165568) | 165568..166128 | + | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
| LMH54_RS29335 (166260) | 166260..166460 | + | 201 | WP_015059022.1 | hypothetical protein | - |
| LMH54_RS29340 (166846) | 166846..167445 | + | 600 | WP_032083981.1 | PIN domain-containing protein | - |
| LMH54_RS29345 (167507) | 167507..167839 | + | 333 | WP_152916585.1 | hypothetical protein | - |
| - (168040) | 168040..168099 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (168040) | 168040..168099 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (168040) | 168040..168099 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (168040) | 168040..168099 | - | 60 | NuclAT_1 | - | Antitoxin |
| LMH54_RS29350 (168144) | 168144..168293 | + | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| LMH54_RS29355 (168577) | 168577..168825 | + | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-65 / fosA3 / blaTEM-1B / rmtB / blaKPC-2 / catA2 | - | 1..169136 | 169136 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T225650 WP_001312851.1 NZ_CP087608:168144-168293 [Klebsiella pneumoniae subsp. pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T225650 NZ_CP121261:2553961-2554143 [Achromobacter spanius]
ATGAATAGCGCCGACATCATCAAACGACTTAAAGCGGATGGCTGGTATCTCGTGCACAGCGTCGGATCACACCACCAGTT
CAAACATCCAACCAAGCGCGGCAAGGTGACCGTGCCTCACCCGCGCAAAGACCTTCCAGCGCCGACAGCGCACAGCATTC
TCAAGCAAGCCGGCTTGAGATAG
ATGAATAGCGCCGACATCATCAAACGACTTAAAGCGGATGGCTGGTATCTCGTGCACAGCGTCGGATCACACCACCAGTT
CAAACATCCAACCAAGCGCGGCAAGGTGACCGTGCCTCACCCGCGCAAAGACCTTCCAGCGCCGACAGCGCACAGCATTC
TCAAGCAAGCCGGCTTGAGATAG
Antitoxin
Download Length: 60 bp
>AT225650 NZ_CP087608:c168099-168040 [Klebsiella pneumoniae subsp. pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
