Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2540162..2540679 | Replicon | chromosome |
| Accession | NZ_CP087593 | ||
| Organism | Staphylococcus aureus strain Newman NM-CQ | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | LO764_RS12995 | Protein ID | WP_000113262.1 |
| Coordinates | 2540162..2540428 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | LO764_RS13000 | Protein ID | WP_000584499.1 |
| Coordinates | 2540428..2540679 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LO764_RS12965 (2535588) | 2535588..2536124 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| LO764_RS12970 (2536357) | 2536357..2537181 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| LO764_RS12975 (2537398) | 2537398..2537580 | - | 183 | WP_000230294.1 | hypothetical protein | - |
| LO764_RS12980 (2537664) | 2537664..2538131 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| LO764_RS12985 (2538317) | 2538317..2539867 | - | 1551 | WP_000727762.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| LO764_RS12990 (2540056) | 2540056..2540127 | - | 72 | Protein_2520 | hypothetical protein | - |
| LO764_RS12995 (2540162) | 2540162..2540428 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| LO764_RS13000 (2540428) | 2540428..2540679 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LO764_RS13005 (2540844) | 2540844..2540945 | - | 102 | WP_001791744.1 | hypothetical protein | - |
| LO764_RS13010 (2540952) | 2540952..2541551 | - | 600 | WP_000162813.1 | DsbA family protein | - |
| LO764_RS13015 (2541570) | 2541570..2541932 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| LO764_RS13020 (2542187) | 2542187..2543437 | + | 1251 | WP_001012222.1 | FemA/FemB family glycyltransferase FmhA | - |
| LO764_RS13025 (2543534) | 2543534..2544265 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| LO764_RS13030 (2544262) | 2544262..2544981 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T225616 WP_000113262.1 NZ_CP087593:c2540428-2540162 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T225616 NZ_CP121222:222727-223125 [Shigella flexneri 2a]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAAAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCTGCAGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGGCTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAACTGAAGACTGGAGCTGA
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAAAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCTGCAGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGGCTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAACTGAAGACTGGAGCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT225616 WP_000584499.1 NZ_CP087593:c2540679-2540428 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT225616 NZ_CP121222:222500-222727 [Shigella flexneri 2a]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAGCGTCAGCACCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAAGAAAGGGAGTCATTCTGA
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAGCGTCAGCACCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAAGAAAGGGAGTCATTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|