Detailed information of TA system TA225615

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2274789..2275006
• Replicon: chromosome
• Accession: NZ_CP087593
• Organism: Staphylococcus aureus strain Newman NM-CQ

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: LO764_RS11610
• Protein ID: WP_001802298.1
• Coordinates: 2274902..2275006 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2274789..2274844 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO764_RS11585	2270992..2271657	-	666	WP_001024094.1	SDR family oxidoreductase	-
LO764_RS11590	2271809..2272129	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
LO764_RS11595	2272131..2273111	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
LO764_RS11600	2273377..2274468	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2274789..2274844	+	56	-	-	Antitoxin
LO764_RS11610	2274902..2275006	-	105	WP_001802298.1	hypothetical protein	Toxin
LO764_RS11615	2275167..2275650	-	484	Protein_2253	recombinase family protein	-
LO764_RS11620	2275693..2276829	-	1137	WP_000115564.1	SAP domain-containing protein	-
LO764_RS11625	2277118..2277210	+	93	WP_001790138.1	hypothetical protein	-
LO764_RS11630	2277499..2277683	+	185	Protein_2256	exotoxin	-
LO764_RS11635	2277915..2278772	-	858	WP_000370924.1	HAD family hydrolase	-
LO764_RS11640	2278840..2279622	-	783	WP_000908177.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T225615 WP_001802298.1 NZ_CP087593:c2275006-2274902 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T225615 NZ_CP121222:c131925-131443 [Shigella flexneri 2a]
ATGGAAATAAATGTCACCGCGCCAGCATTGTTGACGGATGAGCATATACTTCAGCCATTTGACTGTGGAAATGAGGTGCT
AAGTAACTGGTTACGTGGTCGGGCTATGAAAAACCAGATGCTCAATGCTTCTCGCACGTTCGTTATTTGCTTGGAGGATA
CTTTACGTATTGTGGGATACTACTCATTAGCTACTGGTTCCGTCACTCATGCCGAGCTTGGTCGCAGTTTGCGGCATAAC
ATGCCCAATCCTGTCCCTGTTGTTCTGTTAGGGCGTCTGGCTGTTGATGTTTGTACCCAGGGGCATGGTTTCGGTAAATG
GCTACTAAGTGATGCCATTCACCGGGTTGTCAATCTGGCTGATCAGGTTGGCATTAAGGCTGTTATGGTACATGCAATTG
ATGATGACGCCAGAGCATTTTATGAGCGTTTTGGTTTTGTTCAGTCAGTTGTGGCACCTAATACCTTGTTTTATAAAGTC
TGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT225615 NZ_CP087593:2274789-2274844 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin