Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 2235933..2236304 | Replicon | chromosome |
| Accession | NZ_CP087578 | ||
| Organism | Escherichia coli strain OSUCMP42NDM | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | F4VC37 |
| Locus tag | KUA31_RS11035 | Protein ID | WP_001317028.1 |
| Coordinates | 2236110..2236304 (-) | Length | 65 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 2235933..2236111 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KUA31_RS11005 (2230993) | 2230993..2231690 | + | 698 | WP_095033700.1 | IS1-like element IS1B family transposase | - |
| KUA31_RS11010 (2231888) | 2231888..2233261 | + | 1374 | WP_000123738.1 | ATP-dependent RNA helicase DbpA | - |
| KUA31_RS11015 (2233390) | 2233390..2234325 | - | 936 | WP_001157407.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| KUA31_RS11020 (2234377) | 2234377..2235612 | - | 1236 | WP_000040852.1 | site-specific integrase | - |
| KUA31_RS11025 (2235614) | 2235614..2235829 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (2235933) | 2235933..2236111 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (2235933) | 2235933..2236111 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (2235933) | 2235933..2236111 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (2235933) | 2235933..2236111 | + | 179 | NuclAT_0 | - | Antitoxin |
| KUA31_RS11030 (2235908) | 2235908..2236117 | - | 210 | WP_000276809.1 | double-strand break reduction protein RcbA | - |
| KUA31_RS11035 (2236110) | 2236110..2236304 | - | 195 | WP_001317028.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| KUA31_RS11040 (2236361) | 2236361..2237170 | - | 810 | WP_000166319.1 | recombination protein RecT | - |
| KUA31_RS11045 (2237163) | 2237163..2239763 | - | 2601 | WP_073553840.1 | exodeoxyribonuclease VIII | - |
| KUA31_RS11050 (2239865) | 2239865..2240140 | - | 276 | WP_000632297.1 | protein RacC | - |
| KUA31_RS11055 (2240215) | 2240215..2240385 | - | 171 | WP_001352098.1 | YdaE family protein | - |
| KUA31_RS11060 (2240385) | 2240385..2240606 | - | 222 | WP_000560225.1 | killing protein KilR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2231313..2231690 | 377 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7018.89 Da Isoelectric Point: 8.9538
>T225556 WP_001317028.1 NZ_CP087578:c2236304-2236110 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
Download Length: 195 bp
>T225556 NZ_CP121189:2192819-2192922 [Salmonella enterica subsp. enterica serovar Indiana]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 179 bp
>AT225556 NZ_CP087578:2235933-2236111 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
