Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2555580..2555764 Replicon chromosome
Accession NC_010079
Organism Staphylococcus aureus subsp. aureus USA300 TCH1516

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag USA300HOU_RS13165 Protein ID WP_000482650.1
Coordinates 2555657..2555764 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2555580..2555640 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
USA300HOU_RS13140 2551110..2551277 - 168 WP_001790576.1 hypothetical protein -
USA300HOU_RS13150 2551508..2553241 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
USA300HOU_RS13155 2553266..2555029 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2555580..2555640 + 61 - - Antitoxin
USA300HOU_RS13165 2555657..2555764 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
USA300HOU_RS13170 2555898..2556284 - 387 WP_000779358.1 flippase GtxA -
USA300HOU_RS13175 2556552..2557694 + 1143 WP_001176863.1 glycerate kinase -
USA300HOU_RS13180 2557754..2558413 + 660 WP_000831298.1 membrane protein -
USA300HOU_RS13185 2558595..2559806 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
USA300HOU_RS13190 2559929..2560402 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T22554 WP_000482650.1 NC_010079:c2555764-2555657 [Staphylococcus aureus subsp. aureus USA300_TCH1516]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T22554 NC_010079:c2555764-2555657 [Staphylococcus aureus subsp. aureus USA300_TCH1516]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT22554 NC_010079:2555580-2555640 [Staphylococcus aureus subsp. aureus USA300_TCH1516]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References