Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
Location | 2146137..2146830 | Replicon | chromosome |
Accession | NZ_CP087570 | ||
Organism | Escherichia coli strain 114 |
Toxin (Protein)
Gene name | mqsR | Uniprot ID | U9ZN09 |
Locus tag | LOS76_RS10295 | Protein ID | WP_000415585.1 |
Coordinates | 2146137..2146433 (+) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | mqsA | Uniprot ID | S1EBV2 |
Locus tag | LOS76_RS10300 | Protein ID | WP_000650107.1 |
Coordinates | 2146435..2146830 (+) | Length | 132 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LOS76_RS10260 (2141272) | 2141272..2141781 | + | 510 | WP_231364094.1 | Hcp family type VI secretion system effector | - |
LOS76_RS10265 (2141753) | 2141753..2142463 | + | 711 | WP_000834030.1 | hypothetical protein | - |
LOS76_RS10270 (2142470) | 2142470..2142802 | + | 333 | WP_000914690.1 | DUF2645 family protein | - |
LOS76_RS10275 (2142848) | 2142848..2144197 | - | 1350 | WP_000673358.1 | quorum sensing histidine kinase QseC | - |
LOS76_RS10280 (2144194) | 2144194..2144853 | - | 660 | WP_001221502.1 | quorum sensing response regulator transcription factor QseB | - |
LOS76_RS10285 (2145005) | 2145005..2145397 | + | 393 | WP_000712658.1 | OB fold stress tolerance protein YgiW | - |
LOS76_RS10290 (2145450) | 2145450..2145932 | + | 483 | WP_000183505.1 | GyrI-like domain-containing protein | - |
LOS76_RS10295 (2146137) | 2146137..2146433 | + | 297 | WP_000415585.1 | type II toxin-antitoxin system toxin MqsR | Toxin |
LOS76_RS10300 (2146435) | 2146435..2146830 | + | 396 | WP_000650107.1 | type II toxin-antitoxin system antitoxin MqsA | Antitoxin |
LOS76_RS10305 (2146963) | 2146963..2148570 | + | 1608 | WP_001375094.1 | ABC transporter substrate-binding protein | - |
LOS76_RS10310 (2148708) | 2148708..2150966 | + | 2259 | WP_001281841.1 | DNA topoisomerase IV subunit A | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11261.99 Da Isoelectric Point: 8.9070
>T225515 WP_000415585.1 NZ_CP087570:2146137-2146433 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
Download Length: 297 bp
>T225515 NZ_CP121155:c2755911-2755809 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 132 a.a. Molecular weight: 14703.10 Da Isoelectric Point: 9.2136
>AT225515 WP_000650107.1 NZ_CP087570:2146435-2146830 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
Download Length: 396 bp
>AT225515 NZ_CP121155:2755771-2756042 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | U9ZN09 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LU65 |