Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2146137..2146830 Replicon chromosome
Accession NZ_CP087570
Organism Escherichia coli strain 114

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag LOS76_RS10295 Protein ID WP_000415585.1
Coordinates 2146137..2146433 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LOS76_RS10300 Protein ID WP_000650107.1
Coordinates 2146435..2146830 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOS76_RS10260 (2141272) 2141272..2141781 + 510 WP_231364094.1 Hcp family type VI secretion system effector -
LOS76_RS10265 (2141753) 2141753..2142463 + 711 WP_000834030.1 hypothetical protein -
LOS76_RS10270 (2142470) 2142470..2142802 + 333 WP_000914690.1 DUF2645 family protein -
LOS76_RS10275 (2142848) 2142848..2144197 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
LOS76_RS10280 (2144194) 2144194..2144853 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
LOS76_RS10285 (2145005) 2145005..2145397 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LOS76_RS10290 (2145450) 2145450..2145932 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LOS76_RS10295 (2146137) 2146137..2146433 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
LOS76_RS10300 (2146435) 2146435..2146830 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LOS76_RS10305 (2146963) 2146963..2148570 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
LOS76_RS10310 (2148708) 2148708..2150966 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T225515 WP_000415585.1 NZ_CP087570:2146137-2146433 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T225515 NZ_CP121155:c2755911-2755809 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT225515 WP_000650107.1 NZ_CP087570:2146435-2146830 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT225515 NZ_CP121155:2755771-2756042 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References