Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2265478..2265741 Replicon chromosome
Accession NC_010079
Organism Staphylococcus aureus subsp. aureus USA300 TCH1516

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag USA300HOU_RS11595 Protein ID WP_001802298.1
Coordinates 2265637..2265741 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2265478..2265642 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
USA300HOU_RS11575 2261661..2262326 - 666 WP_001024094.1 SDR family oxidoreductase -
USA300HOU_RS11580 2262478..2262798 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
USA300HOU_RS11585 2262800..2263780 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
USA300HOU_RS11590 2264046..2265137 + 1092 WP_000495671.1 lytic regulatory protein -
- 2265478..2265642 + 165 - - Antitoxin
USA300HOU_RS11595 2265637..2265741 - 105 WP_001802298.1 hypothetical protein Toxin
USA300HOU_RS15815 2265902..2266385 - 484 Protein_2204 recombinase family protein -
USA300HOU_RS11605 2266428..2267564 - 1137 WP_000115564.1 SAP domain-containing protein -
USA300HOU_RS11610 2267853..2267945 + 93 WP_001790138.1 hypothetical protein -
USA300HOU_RS11615 2268650..2269507 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
USA300HOU_RS11620 2269575..2270357 - 783 WP_000908176.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T22551 WP_001802298.1 NC_010079:c2265741-2265637 [Staphylococcus aureus subsp. aureus USA300_TCH1516]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T22551 NC_010079:c2265741-2265637 [Staphylococcus aureus subsp. aureus USA300_TCH1516]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT22551 NC_010079:2265478-2265642 [Staphylococcus aureus subsp. aureus USA300_TCH1516]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References