Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4418025..4418749 | Replicon | chromosome |
| Accession | NZ_CP087392 | ||
| Organism | Pectobacterium parvum strain FN20211 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A093VC08 |
| Locus tag | LOZ86_RS19910 | Protein ID | WP_039482109.1 |
| Coordinates | 4418438..4418749 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LOZ86_RS19905 | Protein ID | WP_039482106.1 |
| Coordinates | 4418025..4418441 (-) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOZ86_RS19880 (LOZ86_19880) | 4413519..4414832 | + | 1314 | WP_225969787.1 | MFS transporter | - |
| LOZ86_RS19885 (LOZ86_19885) | 4414829..4416181 | + | 1353 | WP_039512786.1 | pyridoxal-dependent decarboxylase | - |
| LOZ86_RS19890 (LOZ86_19890) | 4416275..4416733 | - | 459 | WP_010286715.1 | hypothetical protein | - |
| LOZ86_RS19895 (LOZ86_19895) | 4417161..4417421 | + | 261 | WP_039482487.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LOZ86_RS19900 (LOZ86_19900) | 4417495..4417866 | + | 372 | WP_039482489.1 | helix-turn-helix transcriptional regulator | - |
| LOZ86_RS19905 (LOZ86_19905) | 4418025..4418441 | - | 417 | WP_039482106.1 | helix-turn-helix domain-containing protein | Antitoxin |
| LOZ86_RS19910 (LOZ86_19910) | 4418438..4418749 | - | 312 | WP_039482109.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LOZ86_RS19915 (LOZ86_19915) | 4419324..4419617 | - | 294 | WP_039482111.1 | type I-E CRISPR-associated endoribonuclease Cas2e | - |
| LOZ86_RS19920 (LOZ86_19920) | 4419618..4420538 | - | 921 | WP_039482113.1 | type I-E CRISPR-associated endonuclease Cas1e | - |
| LOZ86_RS19925 (LOZ86_19925) | 4420563..4421210 | - | 648 | WP_039482116.1 | type I-E CRISPR-associated protein Cas6/Cse3/CasE | - |
| LOZ86_RS19930 (LOZ86_19930) | 4421210..4421944 | - | 735 | WP_111778762.1 | type I-E CRISPR-associated protein Cas5/CasD | - |
| LOZ86_RS19935 (LOZ86_19935) | 4421954..4423021 | - | 1068 | WP_039482121.1 | type I-E CRISPR-associated protein Cas7/Cse4/CasC | - |
| LOZ86_RS19940 (LOZ86_19940) | 4423025..4423672 | - | 648 | WP_039482124.1 | type I-E CRISPR-associated protein Cse2/CasB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4417495..4426681 | 9186 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12450.29 Da Isoelectric Point: 9.8530
>T225467 WP_039482109.1 NZ_CP087392:c4418749-4418438 [Pectobacterium parvum]
MHVISRAPFDTATTQFPNQAAALDDLYRVIKREMYATPDDMKKRFPSLDRMKYREKWWVIDIGGGHLRVMFFADFERGKI
FIKHITSHAEYDRLTEYYRRNKE
MHVISRAPFDTATTQFPNQAAALDDLYRVIKREMYATPDDMKKRFPSLDRMKYREKWWVIDIGGGHLRVMFFADFERGKI
FIKHITSHAEYDRLTEYYRRNKE
Download Length: 312 bp
>T225467 NZ_CP121151:3982164-3982382 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15375.68 Da Isoelectric Point: 4.8037
>AT225467 WP_039482106.1 NZ_CP087392:c4418441-4418025 [Pectobacterium parvum]
MMYADAIKAANNLTSIVPFLGGSASRKDYEDALKLTEYLIESEPDSPLIDMLTAKIDKYEDDAPEFAAFNERVKALPAGI
ALLRVLMDQHQLTQSDFEAEIGKKSLVSRILKGERTLTLDHMRALAKRFNIPVSAFVD
MMYADAIKAANNLTSIVPFLGGSASRKDYEDALKLTEYLIESEPDSPLIDMLTAKIDKYEDDAPEFAAFNERVKALPAGI
ALLRVLMDQHQLTQSDFEAEIGKKSLVSRILKGERTLTLDHMRALAKRFNIPVSAFVD
Download Length: 417 bp
>AT225467 NZ_CP121151:3981764-3982138 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|