Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4372125..4372627 Replicon chromosome
Accession NZ_CP087392
Organism Pectobacterium parvum strain FN20211

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6P1S0U5
Locus tag LOZ86_RS19700 Protein ID WP_039482019.1
Coordinates 4372373..4372627 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7W2E625
Locus tag LOZ86_RS19695 Protein ID WP_039324900.1
Coordinates 4372125..4372376 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOZ86_RS19680 (LOZ86_19680) 4368525..4369484 + 960 WP_039512800.1 ABC transporter permease -
LOZ86_RS19685 (LOZ86_19685) 4369477..4370343 + 867 WP_230242654.1 ABC transporter permease -
LOZ86_RS19690 (LOZ86_19690) 4370340..4372049 + 1710 WP_039512799.1 ABC transporter ATP-binding protein -
LOZ86_RS19695 (LOZ86_19695) 4372125..4372376 + 252 WP_039324900.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
LOZ86_RS19700 (LOZ86_19700) 4372373..4372627 + 255 WP_039482019.1 Txe/YoeB family addiction module toxin Toxin
LOZ86_RS19705 (LOZ86_19705) 4372669..4373523 - 855 WP_039482022.1 helix-turn-helix domain-containing protein -
LOZ86_RS19710 (LOZ86_19710) 4373548..4374387 - 840 WP_039482025.1 HTH-type transcriptional activator RhaS -
LOZ86_RS19715 (LOZ86_19715) 4374723..4376213 + 1491 WP_039482028.1 rhamnulokinase -
LOZ86_RS19720 (LOZ86_19720) 4376210..4377472 + 1263 WP_039482031.1 L-rhamnose isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10211.76 Da        Isoelectric Point: 8.0353

>T225466 WP_039482019.1 NZ_CP087392:4372373-4372627 [Pectobacterium parvum]
VKLIWSEEAWEDYLYWQDIDKRIVKKINELIKETRRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYAITDDAMMIAAC
RYHY

Download         Length: 255 bp

>T225466 NZ_CP121151:c3202314-3201937 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9367.64 Da        Isoelectric Point: 4.6119

>AT225466 WP_039324900.1 NZ_CP087392:4372125-4372376 [Pectobacterium parvum]
MRTISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAKRLMNSIESLKAGNGEERD
IIE

Download         Length: 252 bp

>AT225466 NZ_CP121151:c3202772-3202404 [Escherichia coli]
GTGTCAGACACGTTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAACATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGATACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1S0U5

Antitoxin

Source ID Structure
AlphaFold DB A0A7W2E625

References