Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
| Location | 259447..260798 | Replicon | chromosome |
| Accession | NZ_CP087392 | ||
| Organism | Pectobacterium parvum strain FN20211 | ||
Toxin (Protein)
| Gene name | HipT | Uniprot ID | A0A6P1S2T8 |
| Locus tag | LOZ86_RS01115 | Protein ID | WP_039483287.1 |
| Coordinates | 259447..260487 (-) | Length | 347 a.a. |
Antitoxin (Protein)
| Gene name | HipS | Uniprot ID | A0A6P1S6U4 |
| Locus tag | LOZ86_RS01120 | Protein ID | WP_039483284.1 |
| Coordinates | 260484..260798 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOZ86_RS01090 (LOZ86_01090) | 256084..256473 | + | 390 | WP_039513346.1 | Mor transcription activator family protein | - |
| LOZ86_RS01095 (LOZ86_01095) | 256542..256901 | - | 360 | WP_039483297.1 | hypothetical protein | - |
| LOZ86_RS01100 (LOZ86_01100) | 256966..257568 | - | 603 | WP_039483294.1 | hypothetical protein | - |
| LOZ86_RS01105 (LOZ86_01105) | 258026..258931 | + | 906 | WP_039483290.1 | siderophore-interacting protein | - |
| LOZ86_RS01110 (LOZ86_01110) | 259019..259336 | - | 318 | Protein_215 | thiol:disulfide interchange protein DsbG | - |
| LOZ86_RS01115 (LOZ86_01115) | 259447..260487 | - | 1041 | WP_039483287.1 | HipA domain-containing protein | Toxin |
| LOZ86_RS01120 (LOZ86_01120) | 260484..260798 | - | 315 | WP_039483284.1 | HipA N-terminal domain-containing protein | Antitoxin |
| LOZ86_RS01125 (LOZ86_01125) | 260783..261109 | - | 327 | WP_039483282.1 | helix-turn-helix domain-containing protein | - |
| LOZ86_RS01130 (LOZ86_01130) | 261297..262430 | - | 1134 | WP_039483273.1 | alkylhydroperoxidase domain protein | - |
| LOZ86_RS01135 (LOZ86_01135) | 262427..263461 | - | 1035 | WP_039483271.1 | putative FMN-dependent luciferase-like monooxygenase | - |
| LOZ86_RS01140 (LOZ86_01140) | 263509..265170 | - | 1662 | WP_165707380.1 | ABC transporter ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 347 a.a. Molecular weight: 39676.76 Da Isoelectric Point: 6.7797
>T225453 WP_039483287.1 NZ_CP087392:c260487-259447 [Pectobacterium parvum]
MIRCRILLTPLTHEEEIATGYSRKGLKHLTGSMHASSTLRFTRQQFMHDLPQAQKGMSISGYQPKIQMVLEERAFTVVDH
QGLYILKPSPIEFPHLAENEHATMTLMARLRFAVPPHGLLRFKPEQADDEPEFAFVIKRFDRDEKTGHPIHQEQLDGAMG
IGEKFGKIHTDGRQYVSYERLALFLSKHVNDNIVFKIDLFRRIAYAYMLGNNDMHLRNFGLIHSRSGSLMLAPIYDFVSV
APYPTYFSSCFMALPLLIQEEGDEALAPGFETAYGEYLGMDFILFGQRIGLSENLTKKLLADFLKEAECVESTYRDSFMP
ADAIETTLRCYRHRLKLMSILDAERI
MIRCRILLTPLTHEEEIATGYSRKGLKHLTGSMHASSTLRFTRQQFMHDLPQAQKGMSISGYQPKIQMVLEERAFTVVDH
QGLYILKPSPIEFPHLAENEHATMTLMARLRFAVPPHGLLRFKPEQADDEPEFAFVIKRFDRDEKTGHPIHQEQLDGAMG
IGEKFGKIHTDGRQYVSYERLALFLSKHVNDNIVFKIDLFRRIAYAYMLGNNDMHLRNFGLIHSRSGSLMLAPIYDFVSV
APYPTYFSSCFMALPLLIQEEGDEALAPGFETAYGEYLGMDFILFGQRIGLSENLTKKLLADFLKEAECVESTYRDSFMP
ADAIETTLRCYRHRLKLMSILDAERI
Download Length: 1041 bp
>T225453 NZ_CP121151:c590788-590324 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11868.62 Da Isoelectric Point: 8.3774
>AT225453 WP_039483284.1 NZ_CP087392:c260798-260484 [Pectobacterium parvum]
MRRQVKVYLYGVHIGQLSQDDEGYLFEYKKSYIGPPLSLSLPIQTGTFHSKTLPPYFASLAPEGWLRRQYSQLQHLDEKD
LFGILIQNGKNLIGAVQLIAEDKS
MRRQVKVYLYGVHIGQLSQDDEGYLFEYKKSYIGPPLSLSLPIQTGTFHSKTLPPYFASLAPEGWLRRQYSQLQHLDEKD
LFGILIQNGKNLIGAVQLIAEDKS
Download Length: 315 bp
>AT225453 NZ_CP121151:c591123-590788 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1S2T8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1S6U4 |