Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 136858..137712 Replicon chromosome
Accession NZ_CP087392
Organism Pectobacterium parvum strain FN20211

Toxin (Protein)


Gene name yhaV Uniprot ID A0A6P1S1D5
Locus tag LOZ86_RS00575 Protein ID WP_039487843.1
Coordinates 136858..137346 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A6P1S4C9
Locus tag LOZ86_RS00580 Protein ID WP_039487859.1
Coordinates 137371..137712 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOZ86_RS00555 (LOZ86_00555) 133381..134049 + 669 WP_039487849.1 6-phosphogluconate phosphatase -
LOZ86_RS00560 (LOZ86_00560) 134069..134797 - 729 WP_039487847.1 amino acid ABC transporter permease -
LOZ86_RS00565 (LOZ86_00565) 134799..135542 - 744 WP_039487846.1 amino acid ABC transporter permease -
LOZ86_RS00570 (LOZ86_00570) 135823..136659 - 837 WP_039487845.1 ABC transporter substrate-binding protein -
LOZ86_RS00575 (LOZ86_00575) 136858..137346 - 489 WP_039487843.1 type II toxin-antitoxin system YhaV family toxin Toxin
LOZ86_RS00580 (LOZ86_00580) 137371..137712 - 342 WP_039487859.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
LOZ86_RS00585 (LOZ86_00585) 138045..139223 - 1179 WP_230242761.1 benzoate/H(+) symporter BenE family transporter -
LOZ86_RS00590 (LOZ86_00590) 139315..139881 + 567 WP_230242762.1 XRE family transcriptional regulator -
LOZ86_RS00595 (LOZ86_00595) 139942..140673 - 732 WP_039487837.1 phosphate signaling complex protein PhoU -
LOZ86_RS00600 (LOZ86_00600) 140686..141459 - 774 WP_039487836.1 phosphate ABC transporter ATP-binding protein PstB -
LOZ86_RS00605 (LOZ86_00605) 141546..142433 - 888 WP_039275952.1 phosphate ABC transporter permease PstA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-148)

Antitoxin

PrlF antitoxin

(15-113)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 18690.49 Da        Isoelectric Point: 6.8563

>T225452 WP_039487843.1 NZ_CP087392:c137346-136858 [Pectobacterium parvum]
MEYLDVNGWKICFHSCFLQQIAELAQKVVELKAAKPDEYLGKKETKLLHAIERVIEEWIAVDPLNPQYRQGDTLGDEFKH
WFRAKFLSQFRLFYRCSAEHKTIIIGWVNDFDTLRAYGSKTDAYKVFAGMLRAGEPPDDWEKLLNEAKAITATTSIPGFL
GK

Download         Length: 489 bp

>T225452 NZ_CP121151:284981-285493 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATGGGGAGCAACACTGGT
TGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCGAGGCGCTGAATAAAA
AAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTATTTTTCCCAACCAAA
TCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12567.24 Da        Isoelectric Point: 4.4335

>AT225452 WP_039487859.1 NZ_CP087392:c137712-137371 [Pectobacterium parvum]
MAIQINTADVSLRAESRLTERSQTTIPAAIRDALHLKPGEYIKYTLLAGGKVIMSRQEEEQDDPVVSQFLTFLENDMKKN
PQNIHSIPVAFWESVKALTAGVEVDLDAPLTDD

Download         Length: 342 bp

>AT225452 NZ_CP121151:284708-284974 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1S1D5

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1S4C9

References