Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1151507..1152182 Replicon chromosome
Accession NZ_CP087390
Organism Enterobacter sp. AN-K1

Toxin (Protein)


Gene name higB Uniprot ID A0A837FDC1
Locus tag LOC22_RS05505 Protein ID WP_015571638.1
Coordinates 1151507..1151806 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LOC22_RS05510 Protein ID WP_032654721.1
Coordinates 1151817..1152182 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOC22_RS05495 (LOC22_05495) 1147884..1150076 + 2193 WP_045906891.1 type I secretion system permease/ATPase -
LOC22_RS05500 (LOC22_05500) 1150057..1151256 + 1200 WP_017382757.1 HlyD family efflux transporter periplasmic adaptor subunit -
LOC22_RS05505 (LOC22_05505) 1151507..1151806 + 300 WP_015571638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOC22_RS05510 (LOC22_05510) 1151817..1152182 + 366 WP_032654721.1 HigA family addiction module antitoxin Antitoxin
LOC22_RS05515 (LOC22_05515) 1152209..1153390 - 1182 WP_017382758.1 PLP-dependent aminotransferase family protein -
LOC22_RS05520 (LOC22_05520) 1153411..1154298 - 888 WP_015571641.1 LysR family transcriptional regulator -
LOC22_RS05525 (LOC22_05525) 1154396..1154998 + 603 WP_033487546.1 short chain dehydrogenase -
LOC22_RS05530 (LOC22_05530) 1155109..1156488 - 1380 WP_230239416.1 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-71)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11624.29 Da        Isoelectric Point: 9.6776

>T225441 WP_015571638.1 NZ_CP087390:1151507-1151806 [Enterobacter sp. AN-K1]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T225441 NZ_CP121149:2830049-2830156 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13731.81 Da        Isoelectric Point: 9.5936

>AT225441 WP_032654721.1 NZ_CP087390:1151817-1152182 [Enterobacter sp. AN-K1]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKLGKPDVTLHGNSA

Download         Length: 366 bp

>AT225441 NZ_CP121149:c2830001-2829934 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FDC1

Antitoxin

Source ID Structure

References