Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 850263..850854 | Replicon | chromosome |
| Accession | NZ_CP087381 | ||
| Organism | Desulfovibrio subterraneus strain ND17 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | LN040_RS03870 | Protein ID | WP_269891484.1 |
| Coordinates | 850263..850541 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LN040_RS03875 | Protein ID | WP_269891485.1 |
| Coordinates | 850552..850854 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LN040_RS03845 (LN040_03835) | 845740..846663 | - | 924 | WP_269891479.1 | hypothetical protein | - |
| LN040_RS03850 (LN040_03840) | 846667..847059 | - | 393 | WP_269891480.1 | hypothetical protein | - |
| LN040_RS03855 (LN040_03845) | 847071..848393 | - | 1323 | WP_269891481.1 | phage tail protein | - |
| LN040_RS03860 (LN040_03850) | 848394..848993 | - | 600 | WP_269891482.1 | phage tail protein | - |
| LN040_RS03865 (LN040_03855) | 848993..850174 | - | 1182 | WP_269891483.1 | baseplate J/gp47 family protein | - |
| LN040_RS03870 (LN040_03860) | 850263..850541 | + | 279 | WP_269891484.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LN040_RS03875 (LN040_03865) | 850552..850854 | + | 303 | WP_269891485.1 | HigA family addiction module antitoxin | Antitoxin |
| LN040_RS03880 (LN040_03870) | 850867..851046 | + | 180 | WP_269891486.1 | hypothetical protein | - |
| LN040_RS03885 (LN040_03875) | 851054..851389 | - | 336 | WP_269891487.1 | DUF2590 family protein | - |
| LN040_RS03890 (LN040_03880) | 851393..853180 | - | 1788 | WP_269891488.1 | phage tail tape measure protein | - |
| LN040_RS03895 (LN040_03885) | 853187..853354 | - | 168 | WP_174404717.1 | hypothetical protein | - |
| LN040_RS03900 (LN040_03890) | 853372..853638 | - | 267 | WP_269891489.1 | putative phage tail assembly chaperone | - |
| LN040_RS03905 (LN040_03895) | 853655..853921 | - | 267 | WP_269891490.1 | hypothetical protein | - |
| LN040_RS03910 (LN040_03900) | 853918..854394 | - | 477 | WP_269891491.1 | 3TM-type holin | - |
| LN040_RS03915 (LN040_03905) | 854397..854810 | - | 414 | WP_269891492.1 | structural protein | - |
| LN040_RS03920 (LN040_03910) | 854807..855019 | - | 213 | WP_269891493.1 | TraR/DksA family transcriptional regulator | - |
| LN040_RS03925 (LN040_03915) | 855025..855471 | - | 447 | WP_269891494.1 | DUF2597 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 843388..878590 | 35202 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10702.10 Da Isoelectric Point: 8.5975
>T225431 WP_269891484.1 NZ_CP087381:850263-850541 [Desulfovibrio subterraneus]
MIRSFAHKGLEDLFYDGTTKGVQQKHVRKLLDILDRLDHAREIRDMNFPGSGLHPLKGGLAEHWSVKVSGNWRITFRFEN
GDAHIVNYQDYH
MIRSFAHKGLEDLFYDGTTKGVQQKHVRKLLDILDRLDHAREIRDMNFPGSGLHPLKGGLAEHWSVKVSGNWRITFRFEN
GDAHIVNYQDYH
Download Length: 279 bp
>T225431 NZ_CP121149:c609282-608818 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11244.16 Da Isoelectric Point: 11.4483
>AT225431 WP_269891485.1 NZ_CP087381:850552-850854 [Desulfovibrio subterraneus]
MRTRTRKPTHPGGILFRMHMEPLGITITALAKRLGISRKTLSAIVNERAPITPDIALRLSRALDTTPELWLGMQQTFTLW
EVAHSNTEWLSVEPIKTANA
MRTRTRKPTHPGGILFRMHMEPLGITITALAKRLGISRKTLSAIVNERAPITPDIALRLSRALDTTPELWLGMQQTFTLW
EVAHSNTEWLSVEPIKTANA
Download Length: 303 bp
>AT225431 NZ_CP121149:c609617-609282 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|