Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 842750..843351 Replicon chromosome
Accession NZ_CP087381
Organism Desulfovibrio subterraneus strain ND17

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LN040_RS03820 Protein ID WP_269891474.1
Coordinates 842750..843034 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LN040_RS03825 Protein ID WP_269891475.1
Coordinates 843052..843351 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN040_RS03790 (LN040_03780) 838614..838865 + 252 WP_269891468.1 toxin HicA -
LN040_RS03795 (LN040_03785) 838862..839185 + 324 WP_269891469.1 toxin-antitoxin system HicB family antitoxin -
LN040_RS03800 (LN040_03790) 839262..839858 - 597 WP_269891470.1 hypothetical protein -
LN040_RS03805 (LN040_03795) 840060..840314 - 255 WP_269891471.1 hypothetical protein -
LN040_RS03810 (LN040_03800) 840629..841258 - 630 WP_269891472.1 HEPN domain-containing protein -
LN040_RS03815 (LN040_03805) 841261..842454 - 1194 WP_269891473.1 DUF262 domain-containing protein -
LN040_RS03820 (LN040_03810) 842750..843034 + 285 WP_269891474.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LN040_RS03825 (LN040_03815) 843052..843351 + 300 WP_269891475.1 HigA family addiction module antitoxin Antitoxin
LN040_RS03830 (LN040_03820) 843388..844488 - 1101 WP_269891476.1 hypothetical protein -
LN040_RS03835 (LN040_03825) 844464..845162 - 699 WP_269891477.1 hypothetical protein -
LN040_RS03840 (LN040_03830) 845159..845743 - 585 WP_269891478.1 DNA-binding protein -
LN040_RS03845 (LN040_03835) 845740..846663 - 924 WP_269891479.1 hypothetical protein -
LN040_RS03850 (LN040_03840) 846667..847059 - 393 WP_269891480.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-95)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10800.44 Da        Isoelectric Point: 9.1876

>T225430 WP_269891474.1 NZ_CP087381:842750-843034 [Desulfovibrio subterraneus]
MPPTFKCKKTQALYETGASRQFQAVIKVALRKLDMIFAAAVLEDLRIPPANRLEALKGDRAGQHSIRINDQWRICFEWDT
AQNRASNIEIVDYH

Download         Length: 285 bp

>T225430 NZ_CP121149:288572-288847 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATAGTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11122.88 Da        Isoelectric Point: 9.7130

>AT225430 WP_269891475.1 NZ_CP087381:843052-843351 [Desulfovibrio subterraneus]
MRIKTHPGEVLREEFMVPYKLSASKLSGYLGVPLSRITEIAAEKRGITADTAVRLAKFFGTTPEFWTNLQTQHDLSKVQN
TKTPEIGRIPRCQEVAACF

Download         Length: 300 bp

>AT225430 NZ_CP121149:288844-289203 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References