Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 17281..17939 Replicon plasmid p1DB002
Accession NZ_CP087355
Organism Acinetobacter baumannii strain DB002

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LO000_RS19985 Protein ID WP_000312250.1
Coordinates 17580..17939 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LO000_RS19980 Protein ID WP_001096429.1
Coordinates 17281..17580 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO000_RS19940 12378..13346 - 969 WP_012308653.1 IS30 family transposase -
LO000_RS19945 13692..13949 + 258 WP_000834290.1 hypothetical protein -
LO000_RS19950 13954..14526 + 573 WP_000443897.1 hypothetical protein -
LO000_RS19955 14502..14681 + 180 WP_000387630.1 hypothetical protein -
LO000_RS19960 14698..15327 + 630 WP_000701003.1 hypothetical protein -
LO000_RS19965 15367..15585 + 219 WP_001043201.1 hypothetical protein -
LO000_RS19970 15605..16159 + 555 WP_000790084.1 hypothetical protein -
LO000_RS19975 16209..16745 + 537 WP_057694987.1 hypothetical protein -
LO000_RS19980 17281..17580 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
LO000_RS19985 17580..17939 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LO000_RS19990 18140..18706 + 567 WP_000710385.1 hypothetical protein -
LO000_RS19995 18755..18937 + 183 WP_000373385.1 hypothetical protein -
LO000_RS20000 19004..19702 + 699 WP_000873188.1 hypothetical protein -
LO000_RS20005 19841..20224 + 384 WP_000654348.1 hypothetical protein -
LO000_RS20010 20291..21049 + 759 WP_001053127.1 hypothetical protein -
LO000_RS20015 22104..22418 + 315 WP_000708714.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-VIa - 1..70098 70098


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T225389 WP_000312250.1 NZ_CP087355:c17939-17580 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T225389 NZ_CP121143:4429908-4430276 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT225389 WP_001096429.1 NZ_CP087355:c17580-17281 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT225389 NZ_CP121143:4429690-4429911 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References