Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1056..1707 Replicon plasmid p1DB008
Accession NZ_CP087342
Organism Acinetobacter baumannii strain DB008

Toxin (Protein)


Gene name higB Uniprot ID N8YFZ1
Locus tag LO011_RS18895 Protein ID WP_000269904.1
Coordinates 1351..1707 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LO011_RS18890 Protein ID WP_001129974.1
Coordinates 1056..1358 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO011_RS18880 161..679 - 519 WP_000447195.1 tetratricopeptide repeat protein -
LO011_RS18885 854..1063 - 210 WP_000069475.1 hypothetical protein -
LO011_RS18890 1056..1358 - 303 WP_001129974.1 XRE family transcriptional regulator Antitoxin
LO011_RS18895 1351..1707 - 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LO011_RS18900 2235..2552 - 318 WP_000900860.1 hypothetical protein -
LO011_RS18905 2757..2948 - 192 WP_000102616.1 hypothetical protein -
LO011_RS18910 4317..5240 + 924 WP_000845851.1 replication initiation protein RepM -
LO011_RS18915 5308..5853 + 546 WP_000736775.1 plasmid replication DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..9203 9203


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-81)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13488.42 Da        Isoelectric Point: 5.7104

>T225379 WP_000269904.1 NZ_CP087342:c1707-1351 [Acinetobacter baumannii]
MWTVITTDLFNEWLEQQDEATQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKSNKKRFYTEMLAIADEQYALHLSTLGDQSNG

Download         Length: 357 bp

>T225379 NZ_CP121141:c4567450-4567348 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11150.97 Da        Isoelectric Point: 7.3198

>AT225379 WP_001129974.1 NZ_CP087342:c1358-1056 [Acinetobacter baumannii]
MAKSLQELLASRSPESQARIQKMADELLLESQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT225379 NZ_CP121141:4567341-4567486 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N8YFZ1

Antitoxin

Source ID Structure

References