Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 460..1045 Replicon plasmid p2OC073
Accession NZ_CP087327
Organism Acinetobacter baumannii strain OC073

Toxin (Protein)


Gene name higB Uniprot ID N8ZPD7
Locus tag LO013_RS18920 Protein ID WP_000897309.1
Coordinates 460..780 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LO013_RS18925 Protein ID WP_000369780.1
Coordinates 773..1045 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO013_RS18915 76..273 + 198 WP_000476222.1 hypothetical protein -
LO013_RS18920 460..780 + 321 WP_000897309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LO013_RS18925 773..1045 + 273 WP_000369780.1 NadS family protein Antitoxin
LO013_RS18930 1636..2577 + 942 WP_114237996.1 DUF6508 domain-containing protein -
LO013_RS18935 2775..3341 - 567 WP_000858429.1 plasmid replication DNA-binding protein -
LO013_RS18940 3405..4286 - 882 WP_005804946.1 replication initiation protein RepM -
LO013_RS18945 4836..6005 - 1170 WP_043041652.1 MobA/MobL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10080 10080


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12209.01 Da        Isoelectric Point: 7.9835

>T225362 WP_000897309.1 NZ_CP087327:460-780 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

>T225362 NZ_CP121139:c3056651-3056549 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10122.63 Da        Isoelectric Point: 8.6582

>AT225362 WP_000369780.1 NZ_CP087327:773-1045 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRKEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Download         Length: 273 bp

>AT225362 NZ_CP121139:3056542-3056687 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A855WJQ3

Antitoxin

Source ID Structure

References