Detailed information of TA system TA225323

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4450207..4450429
• Replicon: chromosome
• Accession: NZ_CP087294
• Organism: Escherichia coli strain APEC E956

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: LO740_RS21610
• Protein ID: WP_001295224.1
• Coordinates: 4450207..4450314 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4450371..4450429 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO740_RS21585	4445460..4446212	-	753	WP_000279544.1	cellulose biosynthesis protein BcsQ	-
LO740_RS21590	4446224..4446412	-	189	WP_001063315.1	cellulose biosynthesis protein BcsR	-
LO740_RS21595	4446685..4448256	+	1572	WP_001204944.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
LO740_RS21600	4448253..4448444	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
LO740_RS21605	4448441..4450120	+	1680	WP_001562264.1	cellulose biosynthesis protein BcsG	-
LO740_RS21610	4450207..4450314	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4450371..4450429	+	59	-	-	Antitoxin
LO740_RS21615	4450690..4450797	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
LO740_RS21620	4451173..4451280	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
LO740_RS21625	4451656..4451763	-	108	WP_000170738.1	type I toxin-antitoxin system toxin Ldr family protein	-
LO740_RS21630	4452239..4453510	+	1272	WP_001318103.1	aromatic amino acid transport family protein	-
LO740_RS21635	4453540..4454544	-	1005	WP_000107036.1	dipeptide ABC transporter ATP-binding subunit DppF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T225323 WP_001295224.1 NZ_CP087294:c4450314-4450207 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T225323 NZ_CP121133:509528-509812 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTTAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT225323 NZ_CP087294:4450371-4450429 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin